Hopkins SC - Search Results

1

Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it: a translational imaging study with ketamine.

Kokkinou M, Irvine EE, Bonsall DR, Natesan S, Wells LA, Smith M, Glegola J, Paul EJ, Tossell K, Veronese M, Khadayate S, Dedic N, Hopkins SC, Ungless MA, Withers DJ, Howes OD. Kokkinou M, et al. Among authors: hopkins sc. Mol Psychiatry. 2021 Jun;26(6):2562-2576. doi: 10.1038/s41380-020-0740-6. Epub 2020 May 7. Mol Psychiatry. 2021. PMID: 32382134 Free PMC article.

2

SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D₂ Receptor Mechanism of Action.

Dedic N, Jones PG, Hopkins SC, Lew R, Shao L, Campbell JE, Spear KL, Large TH, Campbell UC, Hanania T, Leahy E, Koblan KS. Dedic N, et al. Among authors: hopkins sc. J Pharmacol Exp Ther. 2019 Oct;371(1):1-14. doi: 10.1124/jpet.119.260281. Epub 2019 Aug 1. J Pharmacol Exp Ther. 2019. PMID: 31371483

3

Effect of TAAR1/5-HT_1A agonist SEP-363856 on REM sleep in humans.

Hopkins SC, Dedic N, Koblan KS. Hopkins SC, et al. Transl Psychiatry. 2021 Apr 20;11(1):228. doi: 10.1038/s41398-021-01331-9. Transl Psychiatry. 2021. PMID: 33879769 Free PMC article. Clinical Trial.

4

Depicting Safety Profile of TAAR1 Agonist Ulotaront Relative to Reactions Anticipated for a Dopamine D2-Based Pharmacological Class in FAERS.

Hopkins SC, Ogirala A, Worden M, Koblan KS. Hopkins SC, et al. Clin Drug Investig. 2021 Dec;41(12):1067-1073. doi: 10.1007/s40261-021-01094-7. Epub 2021 Nov 9. Clin Drug Investig. 2021. PMID: 34751928 Free PMC article. Clinical Trial.

5

Ulotaront, a novel TAAR1 agonist with 5-HT1A agonist activity, lacks abuse liability and attenuates cocaine cue-induced relapse in rats.

Synan C, Bowen C, Heal DJ, Froger-Colléaux C, Beardsley PM, Dedic N, Hopkins SC, Campbell U, Koblan KS. Synan C, et al. Among authors: hopkins sc. Drug Alcohol Depend. 2022 Feb 1;231:109261. doi: 10.1016/j.drugalcdep.2021.109261. Epub 2021 Dec 31. Drug Alcohol Depend. 2022. PMID: 35033729 Free article.

6

Ulotaront: A TAAR1 Agonist for the Treatment of Schizophrenia.

Heffernan MLR, Herman LW, Brown S, Jones PG, Shao L, Hewitt MC, Campbell JE, Dedic N, Hopkins SC, Koblan KS, Xie L. Heffernan MLR, et al. Among authors: hopkins sc. ACS Med Chem Lett. 2021 Dec 6;13(1):92-98. doi: 10.1021/acsmedchemlett.1c00527. eCollection 2022 Jan 13. ACS Med Chem Lett. 2021. PMID: 35047111 Free PMC article.

7

Ulotaront: review of preliminary evidence for the efficacy and safety of a TAAR1 agonist in schizophrenia.

Achtyes ED, Hopkins SC, Dedic N, Dworak H, Zeni C, Koblan K. Achtyes ED, et al. Among authors: hopkins sc. Eur Arch Psychiatry Clin Neurosci. 2023 Oct;273(7):1543-1556. doi: 10.1007/s00406-023-01580-3. Epub 2023 May 10. Eur Arch Psychiatry Clin Neurosci. 2023. PMID: 37165101 Free PMC article. Review.

8

TAAR1 agonist ulotaront modulates striatal and hippocampal glutamate function in a state-dependent manner.

Yang SM, Ghoshal A, Hubbard JM, Gackière F, Teyssié R, Neale SA, Hopkins SC, Koblan KS, Bristow LJ, Dedic N. Yang SM, et al. Among authors: hopkins sc. Neuropsychopharmacology. 2024 Jun;49(7):1091-1103. doi: 10.1038/s41386-023-01779-x. Epub 2023 Dec 19. Neuropsychopharmacology. 2024. PMID: 38110609 Free PMC article.

9

TAAR1 agonists improve glycemic control, reduce body weight and modulate neurocircuits governing energy balance and feeding.

Dedic N, Wang L, Hajos-Korcsok E, Hecksher-Sørensen J, Roostalu U, Vickers SP, Wu S, Anacker C, Synan C, Jones PG, Milanovic S, Hopkins SC, Bristow LJ, Koblan KS. Dedic N, et al. Among authors: hopkins sc. Mol Metab. 2024 Feb;80:101883. doi: 10.1016/j.molmet.2024.101883. Epub 2024 Jan 16. Mol Metab. 2024. PMID: 38237896 Free PMC article.

10

TAAR1 agonist ulotaront delays gastric emptying of solids in patients with schizophrenia and concurrent metabolic syndrome with prediabetes.

Milanović S, Dedic N, Lew R, Burton D, Koblan KS, Camilleri M, Hopkins SC. Milanović S, et al. Among authors: hopkins sc. Diabetes Obes Metab. 2024 Jun;26(6):2466-2475. doi: 10.1111/dom.15569. Epub 2024 Mar 27. Diabetes Obes Metab. 2024. PMID: 38533552 Clinical Trial.

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