Pedersen H - Search Results

1

A C3-specific nanobody that blocks all three activation pathways in the human and murine complement system.

Pedersen H, Jensen RK, Hansen AG, Gadeberg TAF, Thiel S, Laursen NS, Andersen GR. Pedersen H, et al. J Biol Chem. 2020 Jun 26;295(26):8746-8758. doi: 10.1074/jbc.RA119.012339. Epub 2020 May 6. J Biol Chem. 2020. PMID: 32376685 Free PMC article.

2

Complement Receptor 2 Based Immunoassay Measuring Activation of the Complement System at C3-Level in Plasma Samples From Mice and Humans.

Halkjær L, Troldborg A, Pedersen H, Jensen L, Hansen AG, Hansen TK, Bjerre M, Østergaard JA, Thiel S. Halkjær L, et al. Among authors: pedersen h. Front Immunol. 2020 May 5;11:774. doi: 10.3389/fimmu.2020.00774. eCollection 2020. Front Immunol. 2020. PMID: 32431705 Free PMC article.

3

A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity.

Pedersen H, Jensen RK, Jensen JMB, Fox R, Pedersen DV, Olesen HG, Hansen AG, Christiansen D, Mazarakis SMM, Lojek N, Hansen P, Gadeberg TAF, Zarantonello A, Laursen NS, Mollnes TE, Johnson MB, Stevens B, Thiel S, Andersen GR. Pedersen H, et al. Among authors: pedersen dv. J Immunol. 2020 Oct 15;205(8):2287-2300. doi: 10.4049/jimmunol.2000752. Epub 2020 Sep 16. J Immunol. 2020. PMID: 32938727

4

Complement activation in human autoimmune diseases and mouse models; employing a sandwich immunoassay specific for C3dg.

Troldborg A, Halkjær L, Pedersen H, Hansen A, Loft AG, Lindegaard H, Stengaard-Pedersen K, Graversen JH, Palarasah Y, Thiel S. Troldborg A, et al. Among authors: pedersen h. J Immunol Methods. 2020 Nov;486:112866. doi: 10.1016/j.jim.2020.112866. Epub 2020 Sep 15. J Immunol Methods. 2020. PMID: 32941885

5

Substituting the Thiol Ester of Human A2M or C3 with a Disulfide Produces Native Proteins with Altered Proteolysis-Induced Conformational Changes.

Harwood SL, Nielsen NS, Pedersen H, Kjøge K, Nielsen PK, Andersen GR, Enghild JJ. Harwood SL, et al. Among authors: pedersen h. Biochemistry. 2020 Dec 29;59(51):4799-4809. doi: 10.1021/acs.biochem.0c00803. Epub 2020 Dec 10. Biochemistry. 2020. PMID: 33301305

6

Nanobodies Provide Insight into the Molecular Mechanisms of the Complement Cascade and Offer New Therapeutic Strategies.

Zarantonello A, Pedersen H, Laursen NS, Andersen GR. Zarantonello A, et al. Among authors: pedersen h. Biomolecules. 2021 Feb 17;11(2):298. doi: 10.3390/biom11020298. Biomolecules. 2021. PMID: 33671302 Free PMC article. Review.

7

Structural insights into the function-modulating effects of nanobody binding to the integrin receptor α_Mβ₂.

Jensen RK, Pedersen H, Lorentzen J, Laursen NS, Vorup-Jensen T, Andersen GR. Jensen RK, et al. Among authors: pedersen h. J Biol Chem. 2022 Aug;298(8):102168. doi: 10.1016/j.jbc.2022.102168. Epub 2022 Jun 20. J Biol Chem. 2022. PMID: 35738398 Free PMC article.

8

Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity.

Pedersen H, Jensen RK, Hansen AG, Petersen SV, Thiel S, Laursen NS, Andersen GR. Pedersen H, et al. Front Immunol. 2022 Jul 22;13:872536. doi: 10.3389/fimmu.2022.872536. eCollection 2022. Front Immunol. 2022. PMID: 35935935 Free PMC article.

9

Novel homozygous CD46 variant with C-isoform expression affects C3b inactivation in atypical hemolytic uremic syndrome.

Schack VR, Herlin MK, Pedersen H, Jensen JMB, Faerch M, Bundgaard B, Jensen RK, Jensen UB, Christensen R, Andersen GR, Thiel S, Höllsberg P. Schack VR, et al. Among authors: pedersen h. Eur J Immunol. 2022 Oct;52(10):1610-1619. doi: 10.1002/eji.202249838. Epub 2022 Aug 31. Eur J Immunol. 2022. PMID: 35987516 Free PMC article.

10

Filtration and tubular handling of EWE-hC3Nb1, a complement inhibitor nanobody, in wild type mice and a mouse model of proteinuric kidney disease.

Fast MS, Weyer K, Pedersen H, Andersen GR, Birn H. Fast MS, et al. Among authors: pedersen h. FEBS Open Bio. 2024 Feb;14(2):322-330. doi: 10.1002/2211-5463.13752. Epub 2024 Jan 4. FEBS Open Bio. 2024. PMID: 38124617 Free PMC article.

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