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Deficiency in SIRP-α cytoplasmic recruitment confers protection from acute kidney injury.
Ghimire K, Chiba T, Minhas N, Meijles DN, Lu B, O'Connell P, Rogers NM. Ghimire K, et al. Among authors: minhas n. FASEB J. 2019 Oct;33(10):11528-11540. doi: 10.1096/fj.201900583R. Epub 2019 Aug 1. FASEB J. 2019. PMID: 31370677
These results identify parenchymal SIRP-alpha as an independent driver of IR-mediated AKI and a potential therapeutic target.-Ghimire, K., Chiba, T., Minhas, N., Meijles, D. N., Lu, B., O'Connell, P., Rogers, N. M. Deficiency in SIRP-alpha cytoplasmic …
These results identify parenchymal SIRP-alpha as an independent driver of IR-mediated AKI and a potential therapeutic target.-Ghimire, K., C …
The impact of the cytoplasmic ubiquitin ligase TNFAIP3 gene variation on transcription factor NF-κB activation in acute kidney injury.
Rogers NM, Zammit N, Nguyen-Ngo D, Souilmi Y, Minhas N, Meijles DN, Self E, Walters SN, Warren J, Cultrone D, El-Rashid M, Li J, Chtanova T, O'Connell PJ, Grey ST. Rogers NM, et al. Among authors: minhas n. Kidney Int. 2023 Jun;103(6):1105-1119. doi: 10.1016/j.kint.2023.02.030. Epub 2023 Apr 23. Kidney Int. 2023. PMID: 37097268
Thrombospondin-1 Drives Cardiac Remodeling in Chronic Kidney Disease.
Julovi SM, Trinh K, Robertson H, Xu C, Minhas N, Viswanathan S, Patrick E, Horowitz JD, Meijles DN, Rogers NM. Julovi SM, et al. Among authors: minhas n. JACC Basic Transl Sci. 2024 Mar 27;9(5):607-627. doi: 10.1016/j.jacbts.2024.01.010. eCollection 2024 May. JACC Basic Transl Sci. 2024. PMID: 38984053 Free PMC article.
Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function.
Minhas N, Xue M, Fukudome K, Jackson CJ. Minhas N, et al. FASEB J. 2010 Mar;24(3):873-81. doi: 10.1096/fj.09-134445. Epub 2009 Oct 26. FASEB J. 2010. PMID: 19858095
In summary, this study demonstrates that APC has novel effects on the Ang/Tie2 axis, which enhance endothelial barrier function and are likely to contribute to its therapeutic effect in sepsis and other diseases associated with vascular leakage.-Minhas, N., Xue, M., …
In summary, this study demonstrates that APC has novel effects on the Ang/Tie2 axis, which enhance endothelial barrier function and are like …
36 results