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L-Selectin/CD62L is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men.
Drescher HK, Schippers A, Rosenhain S, Gremse F, Bongiovanni L, Bruin A, Eswaran S, Gallage SU, Pfister D, Szydlowska M, Heikenwalder M, Weiskirchen S, Wagner N, Trautwein C, Weiskirchen R, Kroy DC. Drescher HK, et al. Among authors: heikenwalder m. Cells. 2020 Apr 29;9(5):1106. doi: 10.3390/cells9051106. Cells. 2020. PMID: 32365632 Free PMC article.
TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer.
Bettermann K, Vucur M, Haybaeck J, Koppe C, Janssen J, Heymann F, Weber A, Weiskirchen R, Liedtke C, Gassler N, Müller M, de Vos R, Wolf MJ, Boege Y, Seleznik GM, Zeller N, Erny D, Fuchs T, Zoller S, Cairo S, Buendia MA, Prinz M, Akira S, Tacke F, Heikenwalder M, Trautwein C, Luedde T. Bettermann K, et al. Among authors: heikenwalder m. Cancer Cell. 2010 May 18;17(5):481-96. doi: 10.1016/j.ccr.2010.03.021. Cancer Cell. 2010. PMID: 20478530 Free article.
RIP3 inhibits inflammatory hepatocarcinogenesis but promotes cholestasis by controlling caspase-8- and JNK-dependent compensatory cell proliferation.
Vucur M, Reisinger F, Gautheron J, Janssen J, Roderburg C, Cardenas DV, Kreggenwinkel K, Koppe C, Hammerich L, Hakem R, Unger K, Weber A, Gassler N, Luedde M, Frey N, Neumann UP, Tacke F, Trautwein C, Heikenwalder M, Luedde T. Vucur M, et al. Among authors: heikenwalder m. Cell Rep. 2013 Aug 29;4(4):776-90. doi: 10.1016/j.celrep.2013.07.035. Epub 2013 Aug 22. Cell Rep. 2013. PMID: 23972991 Free article.
A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis.
Gautheron J, Vucur M, Reisinger F, Cardenas DV, Roderburg C, Koppe C, Kreggenwinkel K, Schneider AT, Bartneck M, Neumann UP, Canbay A, Reeves HL, Luedde M, Tacke F, Trautwein C, Heikenwalder M, Luedde T. Gautheron J, et al. Among authors: heikenwalder m. EMBO Mol Med. 2014 Aug;6(8):1062-74. doi: 10.15252/emmm.201403856. EMBO Mol Med. 2014. PMID: 24963148 Free PMC article.
The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance.
Gautheron J, Vucur M, Schneider AT, Severi I, Roderburg C, Roy S, Bartneck M, Schrammen P, Diaz MB, Ehling J, Gremse F, Heymann F, Koppe C, Lammers T, Kiessling F, Van Best N, Pabst O, Courtois G, Linkermann A, Krautwald S, Neumann UP, Tacke F, Trautwein C, Green DR, Longerich T, Frey N, Luedde M, Bluher M, Herzig S, Heikenwalder M, Luedde T. Gautheron J, et al. Among authors: heikenwalder m. Nat Commun. 2016 Jun 21;7:11869. doi: 10.1038/ncomms11869. Nat Commun. 2016. PMID: 27323669 Free PMC article.
IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1.
Koppe C, Verheugd P, Gautheron J, Reisinger F, Kreggenwinkel K, Roderburg C, Quagliata L, Terracciano L, Gassler N, Tolba RH, Boege Y, Weber A, Karin M, Luedde M, Neumann UP, Weiskirchen R, Tacke F, Vucur M, Trautwein C, Lüscher B, Preisinger C, Heikenwalder M, Luedde T. Koppe C, et al. Among authors: heikenwalder m. Hepatology. 2016 Oct;64(4):1217-31. doi: 10.1002/hep.28723. Epub 2016 Aug 11. Hepatology. 2016. PMID: 27396433
The immunology of hepatocellular carcinoma.
Ringelhan M, Pfister D, O'Connor T, Pikarsky E, Heikenwalder M. Ringelhan M, et al. Among authors: heikenwalder m. Nat Immunol. 2018 Mar;19(3):222-232. doi: 10.1038/s41590-018-0044-z. Epub 2018 Jan 29. Nat Immunol. 2018. PMID: 29379119 Review.
346 results