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Development of a polygenic risk score to improve screening for fracture risk: A genetic risk prediction study.
Forgetta V, Keller-Baruch J, Forest M, Durand A, Bhatnagar S, Kemp JP, Nethander M, Evans D, Morris JA, Kiel DP, Rivadeneira F, Johansson H, Harvey NC, Mellström D, Karlsson M, Cooper C, Evans DM, Clarke R, Kanis JA, Orwoll E, McCloskey EV, Ohlsson C, Pineau J, Leslie WD, Greenwood CMT, Richards JB. Forgetta V, et al. PLoS Med. 2020 Jul 2;17(7):e1003152. doi: 10.1371/journal.pmed.1003152. eCollection 2020 Jul. PLoS Med. 2020. PMID: 32614825 Free PMC article.
Improved prediction of fracture risk leveraging a genome-wide polygenic risk score.
Lu T, Forgetta V, Keller-Baruch J, Nethander M, Bennett D, Forest M, Bhatnagar S, Walters RG, Lin K, Chen Z, Li L, Karlsson M, Mellström D, Orwoll E, McCloskey EV, Kanis JA, Leslie WD, Clarke RJ, Ohlsson C, Greenwood CMT, Richards JB. Lu T, et al. Genome Med. 2021 Feb 3;13(1):16. doi: 10.1186/s13073-021-00838-6. Genome Med. 2021. PMID: 33536041 Free PMC article.
Considering strategies for SNP selection in genetic and polygenic risk scores.
St-Pierre J, Zhang X, Lu T, Jiang L, Loffree X, Wang L, Bhatnagar S, Greenwood CMT; CANSSI team on Improving Robust High-Dimensional Causal Inference and Prediction Modelling. St-Pierre J, et al. Front Genet. 2022 Oct 25;13:900595. doi: 10.3389/fgene.2022.900595. eCollection 2022. Front Genet. 2022. PMID: 36819922 Free PMC article.
38 results