Wang L - Search Results

1

Basic biochemical characterization of cytosolic enzymes in thymidine nucleotide synthesis in adult rat tissues: implications for tissue specific mitochondrial DNA depletion and deoxynucleoside-based therapy for TK2-deficiency.

Wang L, Sun R, Eriksson S. Wang L, et al. BMC Mol Cell Biol. 2020 Apr 28;21(1):33. doi: 10.1186/s12860-020-00272-3. BMC Mol Cell Biol. 2020. PMID: 32345222 Free PMC article.

2

Mitochondrial deoxyguanosine kinase mutations and mitochondrial DNA depletion syndrome.

Wang L, Eriksson S. Wang L, et al. FEBS Lett. 2003 Nov 20;554(3):319-22. doi: 10.1016/s0014-5793(03)01181-5. FEBS Lett. 2003. PMID: 14623087 Free article.

3

Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes.

Wang L, Limongelli A, Vila MR, Carrara F, Zeviani M, Eriksson S. Wang L, et al. Mol Genet Metab. 2005 Jan;84(1):75-82. doi: 10.1016/j.ymgme.2004.09.005. Mol Genet Metab. 2005. PMID: 15639197

4

Molecular mechanisms of mitochondrial DNA depletion diseases caused by deficiencies in enzymes in purine and pyrimidine metabolism.

Eriksson S, Wang L. Eriksson S, et al. Among authors: wang l. Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):800-8. doi: 10.1080/15257770802146197. Nucleosides Nucleotides Nucleic Acids. 2008. PMID: 18600543 Review.

5

5-Bromovinyl 2'-deoxyuridine phosphorylation by mitochondrial and cytosolic thymidine kinase (TK2 and TK1) and its use in selective measurement of TK2 activity in crude extracts.

Wang L, Eriksson S. Wang L, et al. Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):858-62. doi: 10.1080/15257770802146510. Nucleosides Nucleotides Nucleic Acids. 2008. PMID: 18600552

6

The kinetic effects on thymidine kinase 2 by enzyme-bound dTTP may explain the mitochondrial side effects of antiviral thymidine analogs.

Wang L, Sun R, Eriksson S. Wang L, et al. Antimicrob Agents Chemother. 2011 Jun;55(6):2552-8. doi: 10.1128/AAC.00109-11. Epub 2011 Mar 28. Antimicrob Agents Chemother. 2011. PMID: 21444706 Free PMC article.

7

Oxidative stress induced S-glutathionylation and proteolytic degradation of mitochondrial thymidine kinase 2.

Sun R, Eriksson S, Wang L. Sun R, et al. Among authors: wang l. J Biol Chem. 2012 Jul 13;287(29):24304-12. doi: 10.1074/jbc.M112.381996. Epub 2012 Jun 1. J Biol Chem. 2012. PMID: 22661713 Free PMC article.

8

Mitochondrial thymidine kinase 2 but not deoxyguanosine kinase is up-regulated during the stationary growth phase of cultured cells.

Sun R, Eriksson S, Wang L. Sun R, et al. Among authors: wang l. Nucleosides Nucleotides Nucleic Acids. 2014;33(4-6):282-6. doi: 10.1080/15257770.2013.854383. Nucleosides Nucleotides Nucleic Acids. 2014. PMID: 24940680

9

Zidovudine induces downregulation of mitochondrial deoxynucleoside kinases: implications for mitochondrial toxicity of antiviral nucleoside analogs.

Sun R, Eriksson S, Wang L. Sun R, et al. Among authors: wang l. Antimicrob Agents Chemother. 2014 Nov;58(11):6758-66. doi: 10.1128/AAC.03613-14. Epub 2014 Sep 2. Antimicrob Agents Chemother. 2014. PMID: 25182642 Free PMC article.

10

Thymidine kinase 2 enzyme kinetics elucidate the mechanism of thymidine-induced mitochondrial DNA depletion.

Sun R, Wang L. Sun R, et al. Among authors: wang l. Biochemistry. 2014 Oct 7;53(39):6142-50. doi: 10.1021/bi5006877. Epub 2014 Sep 23. Biochemistry. 2014. PMID: 25215937 Review.

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