Rosen N - Search Results

1

RAF dimer inhibition enhances the antitumor activity of MEK inhibitors in K-RAS mutant tumors.

Yuan X, Tang Z, Du R, Yao Z, Cheung SH, Zhang X, Wei J, Zhao Y, Du Y, Liu Y, Hu X, Gong W, Liu Y, Gao Y, Huang Z, Cao Z, Wei M, Zhou C, Wang L, Rosen N, Smith PD, Luo L. Yuan X, et al. Among authors: rosen n. Mol Oncol. 2020 Aug;14(8):1833-1849. doi: 10.1002/1878-0261.12698. Epub 2020 May 18. Mol Oncol. 2020. PMID: 32336014 Free PMC article.

2

Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol.

Solit DB, Basso AD, Olshen AB, Scher HI, Rosen N. Solit DB, et al. Among authors: rosen n. Cancer Res. 2003 May 1;63(9):2139-44. Cancer Res. 2003. PMID: 12727831

3

BRAF mutation predicts sensitivity to MEK inhibition.

Solit DB, Garraway LA, Pratilas CA, Sawai A, Getz G, Basso A, Ye Q, Lobo JM, She Y, Osman I, Golub TR, Sebolt-Leopold J, Sellers WR, Rosen N. Solit DB, et al. Among authors: rosen n. Nature. 2006 Jan 19;439(7074):358-62. doi: 10.1038/nature04304. Epub 2005 Nov 6. Nature. 2006. PMID: 16273091 Free PMC article.

4

V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors.

Grbovic OM, Basso AD, Sawai A, Ye Q, Friedlander P, Solit D, Rosen N. Grbovic OM, et al. Among authors: rosen n. Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):57-62. doi: 10.1073/pnas.0609973103. Epub 2005 Dec 21. Proc Natl Acad Sci U S A. 2006. PMID: 16371460 Free PMC article.

5

3'-deoxy-3'-[18F]fluorothymidine positron emission tomography is a sensitive method for imaging the response of BRAF-dependent tumors to MEK inhibition.

Solit DB, Santos E, Pratilas CA, Lobo J, Moroz M, Cai S, Blasberg R, Sebolt-Leopold J, Larson S, Rosen N. Solit DB, et al. Among authors: rosen n. Cancer Res. 2007 Dec 1;67(23):11463-9. doi: 10.1158/0008-5472.CAN-07-2976. Cancer Res. 2007. PMID: 18056475 Free PMC article.

6

SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase-dependent cancers.

Chandarlapaty S, Sawai A, Ye Q, Scott A, Silinski M, Huang K, Fadden P, Partdrige J, Hall S, Steed P, Norton L, Rosen N, Solit DB. Chandarlapaty S, et al. Among authors: rosen n. Clin Cancer Res. 2008 Jan 1;14(1):240-8. doi: 10.1158/1078-0432.CCR-07-1667. Clin Cancer Res. 2008. PMID: 18172276 Free PMC article.

7

Inhibition of Hsp90 down-regulates mutant epidermal growth factor receptor (EGFR) expression and sensitizes EGFR mutant tumors to paclitaxel.

Sawai A, Chandarlapaty S, Greulich H, Gonen M, Ye Q, Arteaga CL, Sellers W, Rosen N, Solit DB. Sawai A, et al. Among authors: rosen n. Cancer Res. 2008 Jan 15;68(2):589-96. doi: 10.1158/0008-5472.CAN-07-1570. Cancer Res. 2008. PMID: 18199556 Free PMC article.

8

BRAFV600E mutation is associated with preferential sensitivity to mitogen-activated protein kinase kinase inhibition in thyroid cancer cell lines.

Leboeuf R, Baumgartner JE, Benezra M, Malaguarnera R, Solit D, Pratilas CA, Rosen N, Knauf JA, Fagin JA. Leboeuf R, et al. Among authors: rosen n. J Clin Endocrinol Metab. 2008 Jun;93(6):2194-201. doi: 10.1210/jc.2007-2825. Epub 2008 Apr 1. J Clin Endocrinol Metab. 2008. PMID: 18381570 Free PMC article.

9

HER kinase activation confers resistance to MET tyrosine kinase inhibition in MET oncogene-addicted gastric cancer cells.

Bachleitner-Hofmann T, Sun MY, Chen CT, Tang L, Song L, Zeng Z, Shah M, Christensen JG, Rosen N, Solit DB, Weiser MR. Bachleitner-Hofmann T, et al. Among authors: rosen n. Mol Cancer Ther. 2008 Nov;7(11):3499-508. doi: 10.1158/1535-7163.MCT-08-0374. Epub 2008 Oct 30. Mol Cancer Ther. 2008. PMID: 18974395

10

Genetic predictors of MEK dependence in non-small cell lung cancer.

Pratilas CA, Hanrahan AJ, Halilovic E, Persaud Y, Soh J, Chitale D, Shigematsu H, Yamamoto H, Sawai A, Janakiraman M, Taylor BS, Pao W, Toyooka S, Ladanyi M, Gazdar A, Rosen N, Solit DB. Pratilas CA, et al. Among authors: rosen n. Cancer Res. 2008 Nov 15;68(22):9375-83. doi: 10.1158/0008-5472.CAN-08-2223. Cancer Res. 2008. PMID: 19010912 Free PMC article.

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