Edwards JP - Search Results

1

Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach.

Steeneck C, Gege C, Kinzel O, Albers M, Kleymann G, Schlüter T, Schulz A, Xue X, Cummings MD, Fourie AM, Leonard KA, Scott B, Edwards JP, Hoffmann T, Goldberg SD. Steeneck C, et al. Among authors: edwards jp. Bioorg Med Chem Lett. 2020 Jun 15;30(12):127174. doi: 10.1016/j.bmcl.2020.127174. Epub 2020 Apr 7. Bioorg Med Chem Lett. 2020. PMID: 32334912

2

Discovery and preliminary SAR studies of a novel, nonsteroidal progesterone receptor antagonist pharmacophore.

Pooley CL, Edwards JP, Goldman ME, Wang MW, Marschke KB, Crombie DL, Jones TK. Pooley CL, et al. Among authors: edwards jp. J Med Chem. 1998 Aug 27;41(18):3461-6. doi: 10.1021/jm9801915. J Med Chem. 1998. PMID: 9719599

3

New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g] quinolinone.

Edwards JP, West SJ, Pooley CL, Marschke KB, Farmer LJ, Jones TK. Edwards JP, et al. Bioorg Med Chem Lett. 1998 Apr 7;8(7):745-50. doi: 10.1016/s0960-894x(98)00107-3. Bioorg Med Chem Lett. 1998. PMID: 9871534

4

Nonsteroidal progesterone receptor antagonists based on a conformationally-restricted subseries of 6-aryl-1,2-dihydro-2,2,4-trimethylquinolines.

Hamann LG, Winn DT, Pooley CL, Tegley CM, West SJ, Farmer LJ, Zhi L, Edwards JP, Marschke KB, Mais DE, Goldman ME, Jones TK. Hamann LG, et al. Among authors: edwards jp. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2731-6. doi: 10.1016/s0960-894x(98)00482-x. Bioorg Med Chem Lett. 1998. PMID: 9873612

5

5-Alkyl 1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal progesterone receptor modulators.

Zhi L, Tegley CM, Edwards JP, West SJ, Marschke KB, Gottardis MM, Mais DE, Jones TK. Zhi L, et al. Among authors: edwards jp. Bioorg Med Chem Lett. 1998 Dec 1;8(23):3365-70. doi: 10.1016/s0960-894x(98)00608-8. Bioorg Med Chem Lett. 1998. PMID: 9873735

6

Nonsteroidal androgen receptor agonists based on 4-(trifluoromethyl)-2H-pyrano[3,2-g]quinolin-2-one.

Edwards JP, Higuchi RI, Winn DT, Pooley CL, Caferro TR, Hamann LG, Zhi L, Marschke KB, Goldman ME, Jones TK. Edwards JP, et al. Bioorg Med Chem Lett. 1999 Apr 5;9(7):1003-8. doi: 10.1016/s0960-894x(99)00118-3. Bioorg Med Chem Lett. 1999. PMID: 10230628

7

4-Alkyl- and 3,4-dialkyl-1,2,3,4-tetrahydro-8-pyridono[5,6-g]quinolines: potent, nonsteroidal androgen receptor agonists.

Higuchi RI, Edwards JP, Caferro TR, Ringgenberg JD, Kong JW, Hamann LG, Arienti KL, Marschke KB, Davis RL, Farmer LJ, Jones TK. Higuchi RI, et al. Among authors: edwards jp. Bioorg Med Chem Lett. 1999 May 3;9(9):1335-40. doi: 10.1016/s0960-894x(99)00186-9. Bioorg Med Chem Lett. 1999. PMID: 10340624

8

Effects of isosteric pyridone replacements in androgen receptor antagonists based on 1,2-dihydro- and 1,2,3,4-tetrahydro-2,2-dimethyl-6-trifluoromethyl-8-pyridono[5,6-g]quin olines.

Kong JW, Hamann LG, Ruppar DA, Edwards JP, Marschke KB, Jones TK. Kong JW, et al. Among authors: edwards jp. Bioorg Med Chem Lett. 2000 Mar 6;10(5):411-4. doi: 10.1016/s0960-894x(00)00010-x. Bioorg Med Chem Lett. 2000. PMID: 10743937

9

Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4-f]quinoline derivatives as progesterone receptor modulators.

Zhi L, Tegley CM, Pio B, Edwards JP, Jones TK, Marschke KB, Mais DE, Risek B, Schrader WT. Zhi L, et al. Among authors: edwards jp. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2071-4. doi: 10.1016/s0960-894x(03)00255-5. Bioorg Med Chem Lett. 2003. PMID: 12781197

10

Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore.

Zhi L, Ringgenberg JD, Edwards JP, Tegley CM, West SJ, Pio B, Motamedi M, Jones TK, Marschke KB, Mais DE, Schrader WT. Zhi L, et al. Among authors: edwards jp. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2075-8. doi: 10.1016/s0960-894x(03)00256-7. Bioorg Med Chem Lett. 2003. PMID: 12781198

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