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Page 1
A TfR-Binding Cystine-Dense Peptide Promotes Blood-Brain Barrier Penetration of Bioactive Molecules.
Crook ZR, Girard E, Sevilla GP, Merrill M, Friend D, Rupert PB, Pakiam F, Nguyen E, Yin C, Ruff RO, Hopping G, Strand AD, Finton KAK, Coxon M, Mhyre AJ, Strong RK, Olson JM. Crook ZR, et al. Among authors: ruff ro. J Mol Biol. 2020 Jun 26;432(14):3989-4009. doi: 10.1016/j.jmb.2020.04.002. Epub 2020 Apr 15. J Mol Biol. 2020. PMID: 32304700 Free PMC article.
A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure.
Cook Sangar ML, Girard EJ, Hopping G, Yin C, Pakiam F, Brusniak MY, Nguyen E, Ruff R, Gewe MM, Byrnes-Blake K, Nairn NW, Miller DM, Mehlin C, Strand AD, Mhyre AJ, Correnti CE, Strong RK, Simon JA, Olson JM. Cook Sangar ML, et al. Sci Transl Med. 2020 Mar 4;12(533):eaay1041. doi: 10.1126/scitranslmed.aay1041. Sci Transl Med. 2020. PMID: 32132215
Engineering and functionalization of large circular tandem repeat protein nanoparticles.
Correnti CE, Hallinan JP, Doyle LA, Ruff RO, Jaeger-Ruckstuhl CA, Xu Y, Shen BW, Qu A, Polkinghorn C, Friend DJ, Bandaranayake AD, Riddell SR, Kaiser BK, Stoddard BL, Bradley P. Correnti CE, et al. Among authors: ruff ro. Nat Struct Mol Biol. 2020 Apr;27(4):342-350. doi: 10.1038/s41594-020-0397-5. Epub 2020 Mar 23. Nat Struct Mol Biol. 2020. PMID: 32203491 Free PMC article.
Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager.
Crook ZR, Girard EJ, Sevilla GP, Brusniak MY, Rupert PB, Friend DJ, Gewe MM, Clarke M, Lin I, Ruff R, Pakiam F, Phi TD, Bandaranayake A, Correnti CE, Mhyre AJ, Nairn NW, Strong RK, Olson JM. Crook ZR, et al. Sci Transl Med. 2022 May 18;14(645):eabn0402. doi: 10.1126/scitranslmed.abn0402. Epub 2022 May 18. Sci Transl Med. 2022. PMID: 35584229 Free PMC article.
Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks.
Jaeger-Ruckstuhl CA, Lo Y, Fulton E, Waltner OG, Shabaneh TB, Simon S, Muthuraman PV, Correnti CE, Newsom OJ, Engstrom IA, Kanaan SB, Bhise SS, Peralta JMC, Ruff R, Price JP, Stull SM, Stevens AR, Bugos G, Kluesner MG, Voillet V, Muhunthan V, Morrish F, Olson JM, Gottardo R, Sarthy JF, Henikoff S, Sullivan LB, Furlan SN, Riddell SR. Jaeger-Ruckstuhl CA, et al. Immunity. 2024 Feb 13;57(2):287-302.e12. doi: 10.1016/j.immuni.2024.01.011. Immunity. 2024. PMID: 38354704 Free article.