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Page 1
Interleukin-33 Signaling Controls the Development of Iron-Recycling Macrophages.
Lu Y, Basatemur G, Scott IC, Chiarugi D, Clement M, Harrison J, Jugdaohsingh R, Yu X, Newland SA, Jolin HE, Li X, Chen X, Szymanska M, Haraldsen G, Palmer G, Fallon PG, Cohen ES, McKenzie ANJ, Mallat Z. Lu Y, et al. Among authors: scott ic. Immunity. 2020 May 19;52(5):782-793.e5. doi: 10.1016/j.immuni.2020.03.006. Epub 2020 Apr 8. Immunity. 2020. PMID: 32272082 Free PMC article.
HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33.
Osbourn M, Soares DC, Vacca F, Cohen ES, Scott IC, Gregory WF, Smyth DJ, Toivakka M, Kemter AM, le Bihan T, Wear M, Hoving D, Filbey KJ, Hewitson JP, Henderson H, Gonzàlez-Cìscar A, Errington C, Vermeren S, Astier AL, Wallace WA, Schwarze J, Ivens AC, Maizels RM, McSorley HJ. Osbourn M, et al. Among authors: scott ic. Immunity. 2017 Oct 17;47(4):739-751.e5. doi: 10.1016/j.immuni.2017.09.015. Immunity. 2017. PMID: 29045903 Free PMC article.
A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue.
Rana BMJ, Jou E, Barlow JL, Rodriguez-Rodriguez N, Walker JA, Knox C, Jolin HE, Hardman CS, Sivasubramaniam M, Szeto A, Cohen ES, Scott IC, Sleeman MA, Chidomere CI, Cruz Migoni S, Caamano J, Jorgensen HF, Carobbio S, Vidal-Puig A, McKenzie ANJ. Rana BMJ, et al. Among authors: scott ic. J Exp Med. 2019 Sep 2;216(9):1999-2009. doi: 10.1084/jem.20190689. Epub 2019 Jun 27. J Exp Med. 2019. PMID: 31248899 Free PMC article.
Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction.
England E, Rees DG, Scott IC, Carmen S, Chan DTY, Chaillan Huntington CE, Houslay KF, Erngren T, Penney M, Majithiya JB, Rapley L, Sims DA, Hollins C, Hinchy EC, Strain MD, Kemp BP, Corkill DJ, May RD, Vousden KA, Butler RJ, Mustelin T, Vaughan TJ, Lowe DC, Colley C, Cohen ES. England E, et al. Among authors: scott ic. Sci Rep. 2023 Jun 17;13(1):9825. doi: 10.1038/s41598-023-36642-y. Sci Rep. 2023. PMID: 37330528 Free PMC article.
Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex.
Strickson S, Houslay KF, Negri VA, Ohne Y, Ottosson T, Dodd RB, Huntington CC, Baker T, Li J, Stephenson KE, O'Connor AJ, Sagawe JS, Killick H, Moore T, Rees DG, Koch S, Sanden C, Wang Y, Gubbins E, Ghaedi M, Kolbeck R, Saumyaa S, Erjefält JS, Sims GP, Humbles AA, Scott IC, Romero Ros X, Cohen ES. Strickson S, et al. Among authors: scott ic. Eur Respir J. 2023 Sep 28;62(3):2202210. doi: 10.1183/13993003.02210-2022. Print 2023 Sep. Eur Respir J. 2023. PMID: 37442582 Free PMC article.
A Randomized Phase I Study of the Anti-Interleukin-33 Antibody Tozorakimab in Healthy Adults and Patients With Chronic Obstructive Pulmonary Disease.
Reid F, Singh D, Albayaty M, Moate R, Jimenez E, Sadiq MW, Howe D, Gavala M, Killick H, Williams A, Krishnan S, Godwood A, Shukla A, Hewitt L, Lei A, Kell C, Pandya H, Newcombe P, White N, Scott IC, Cohen ES. Reid F, et al. Among authors: scott ic. Clin Pharmacol Ther. 2024 Mar;115(3):565-575. doi: 10.1002/cpt.3147. Epub 2024 Jan 24. Clin Pharmacol Ther. 2024. PMID: 38115209 Clinical Trial.
Population pharmacokinetic/target engagement modelling of tozorakimab in healthy volunteers and patients with chronic obstructive pulmonary disease.
Sadiq MW, Yu H, Åstrand M, Scott IC, Williams A, Hewitt L, White N, Killick H, Gavala M, Cohen ES, Reid F, Kell C, Pandya H, Jimenez E. Sadiq MW, et al. Among authors: scott ic. Br J Clin Pharmacol. 2024 Dec;90(12):3286-3295. doi: 10.1111/bcp.16195. Epub 2024 Aug 25. Br J Clin Pharmacol. 2024. PMID: 39183511 Free PMC article. Clinical Trial.
152 results