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Structure-guided approach to identify a novel class of anti-leishmaniasis diaryl sulfide compounds targeting the trypanothione metabolism.
Colotti G, Saccoliti F, Gramiccia M, Di Muccio T, Prakash J, Yadav S, Dubey VK, Vistoli G, Battista T, Mocci S, Fiorillo A, Bibi A, Madia VN, Messore A, Costi R, Di Santo R, Ilari A. Colotti G, et al. Among authors: battista t. Amino Acids. 2020 Feb;52(2):247-259. doi: 10.1007/s00726-019-02731-4. Epub 2019 Apr 29. Amino Acids. 2020. PMID: 31037461
Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme.
Turcano L, Battista T, De Haro ET, Missineo A, Alli C, Paonessa G, Colotti G, Harper S, Fiorillo A, Ilari A, Bresciani A. Turcano L, et al. Among authors: battista t. PLoS Negl Trop Dis. 2020 May 21;14(5):e0008339. doi: 10.1371/journal.pntd.0008339. eCollection 2020 May. PLoS Negl Trop Dis. 2020. PMID: 32437349 Free PMC article.
Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases.
Genovese I, Giamogante F, Barazzuol L, Battista T, Fiorillo A, Vicario M, D'Alessandro G, Cipriani R, Limatola C, Rossi D, Sorrentino V, Poser E, Mosca L, Squitieri F, Perluigi M, Arena A, van Petegem F, Tito C, Fazi F, Giorgi C, Calì T, Ilari A, Colotti G. Genovese I, et al. Among authors: battista t. Cell Death Dis. 2020 Oct 15;11(10):861. doi: 10.1038/s41419-020-03063-y. Cell Death Dis. 2020. PMID: 33060591 Free PMC article.
Structural basis of ubiquitination mediated by protein splicing in early Eukarya.
Chiarini V, Fiorillo A, Camerini S, Crescenzi M, Nakamura S, Battista T, Guidoni L, Colotti G, Ilari A. Chiarini V, et al. Among authors: battista t. Biochim Biophys Acta Gen Subj. 2021 May;1865(5):129844. doi: 10.1016/j.bbagen.2021.129844. Epub 2021 Jan 11. Biochim Biophys Acta Gen Subj. 2021. PMID: 33444728
Known Drugs Identified by Structure-Based Virtual Screening Are Able to Bind Sigma-1 Receptor and Increase Growth of Huntington Disease Patient-Derived Cells.
Battista T, Pascarella G, Staid DS, Colotti G, Rosati J, Fiorillo A, Casamassa A, Vescovi AL, Giabbai B, Semrau MS, Fanelli S, Storici P, Squitieri F, Morea V, Ilari A. Battista T, et al. Int J Mol Sci. 2021 Jan 28;22(3):1293. doi: 10.3390/ijms22031293. Int J Mol Sci. 2021. PMID: 33525510 Free PMC article.
111 results