Slupphaug G - Search Results

1

HDACi mediate UNG2 depletion, dysregulated genomic uracil and altered expression of oncoproteins and tumor suppressors in B- and T-cell lines.

Iveland TS, Hagen L, Sharma A, Sousa MML, Sarno A, Wollen KL, Liabakk NB, Slupphaug G. Iveland TS, et al. Among authors: slupphaug g. J Transl Med. 2020 Apr 7;18(1):159. doi: 10.1186/s12967-020-02318-8. J Transl Med. 2020. PMID: 32264925 Free PMC article.

2

hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup.

Kavli B, Sundheim O, Akbari M, Otterlei M, Nilsen H, Skorpen F, Aas PA, Hagen L, Krokan HE, Slupphaug G. Kavli B, et al. Among authors: slupphaug g. J Biol Chem. 2002 Oct 18;277(42):39926-36. doi: 10.1074/jbc.M207107200. Epub 2002 Aug 2. J Biol Chem. 2002. PMID: 12161446 Free article.

3

Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells.

Akbari M, Otterlei M, Peña-Diaz J, Aas PA, Kavli B, Liabakk NB, Hagen L, Imai K, Durandy A, Slupphaug G, Krokan HE. Akbari M, et al. Among authors: slupphaug g. Nucleic Acids Res. 2004 Oct 12;32(18):5486-98. doi: 10.1093/nar/gkh872. Print 2004. Nucleic Acids Res. 2004. PMID: 15479784 Free PMC article.

4

B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.

Kavli B, Andersen S, Otterlei M, Liabakk NB, Imai K, Fischer A, Durandy A, Krokan HE, Slupphaug G. Kavli B, et al. Among authors: slupphaug g. J Exp Med. 2005 Jun 20;201(12):2011-21. doi: 10.1084/jem.20050042. J Exp Med. 2005. PMID: 15967827 Free PMC article.

5

Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.

Sundheim O, Vågbø CB, Bjørås M, Sousa MM, Talstad V, Aas PA, Drabløs F, Krokan HE, Tainer JA, Slupphaug G. Sundheim O, et al. Among authors: slupphaug g. EMBO J. 2006 Jul 26;25(14):3389-97. doi: 10.1038/sj.emboj.7601219. Epub 2006 Jul 6. EMBO J. 2006. PMID: 16858410 Free PMC article.

6

Genomic uracil and human disease.

Hagen L, Peña-Diaz J, Kavli B, Otterlei M, Slupphaug G, Krokan HE. Hagen L, et al. Among authors: slupphaug g. Exp Cell Res. 2006 Aug 15;312(14):2666-72. doi: 10.1016/j.yexcr.2006.06.015. Epub 2006 Jun 21. Exp Cell Res. 2006. PMID: 16860315 Review.

7

DNA-uracil and human pathology.

Sousa MM, Krokan HE, Slupphaug G. Sousa MM, et al. Among authors: slupphaug g. Mol Aspects Med. 2007 Jun-Aug;28(3-4):276-306. doi: 10.1016/j.mam.2007.04.006. Epub 2007 May 18. Mol Aspects Med. 2007. PMID: 17590428 Review.

8

Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.

Hagen L, Kavli B, Sousa MM, Torseth K, Liabakk NB, Sundheim O, Pena-Diaz J, Otterlei M, Hørning O, Jensen ON, Krokan HE, Slupphaug G. Hagen L, et al. Among authors: slupphaug g. EMBO J. 2008 Jan 9;27(1):51-61. doi: 10.1038/sj.emboj.7601958. Epub 2007 Dec 13. EMBO J. 2008. PMID: 18079698 Free PMC article.

9

Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.

Westbye MP, Feyzi E, Aas PA, Vågbø CB, Talstad VA, Kavli B, Hagen L, Sundheim O, Akbari M, Liabakk NB, Slupphaug G, Otterlei M, Krokan HE. Westbye MP, et al. Among authors: slupphaug g. J Biol Chem. 2008 Sep 5;283(36):25046-56. doi: 10.1074/jbc.M803776200. Epub 2008 Jul 3. J Biol Chem. 2008. PMID: 18603530 Free PMC article.

10

The rate of base excision repair of uracil is controlled by the initiating glycosylase.

Visnes T, Akbari M, Hagen L, Slupphaug G, Krokan HE. Visnes T, et al. Among authors: slupphaug g. DNA Repair (Amst). 2008 Nov 1;7(11):1869-81. doi: 10.1016/j.dnarep.2008.07.012. Epub 2008 Sep 4. DNA Repair (Amst). 2008. PMID: 18721906

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