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Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations.
Li J, Fukase Y, Shang Y, Zou W, Muñoz-Félix JM, Buitrago L, van Agthoven J, Zhang Y, Hara R, Tanaka Y, Okamoto R, Yasui T, Nakahata T, Imaeda T, Aso K, Zhou Y, Locuson C, Nesic D, Duggan M, Takagi J, Vaughan RD, Walz T, Hodivala-Dilke K, Teitelbaum SL, Arnaout MA, Filizola M, Foley MA, Coller BS. Li J, et al. Among authors: van agthoven j. ACS Pharmacol Transl Sci. 2019 Aug 2;2(6):387-401. doi: 10.1021/acsptsci.9b00041. eCollection 2019 Dec 13. ACS Pharmacol Transl Sci. 2019. PMID: 32259072 Free PMC article.
Atomic basis for the species-specific inhibition of αV integrins by monoclonal antibody 17E6 is revealed by the crystal structure of αVβ3 ectodomain-17E6 Fab complex.
Mahalingam B, Van Agthoven JF, Xiong JP, Alonso JL, Adair BD, Rui X, Anand S, Mehrbod M, Mofrad MR, Burger C, Goodman SL, Arnaout MA. Mahalingam B, et al. Among authors: van agthoven jf. J Biol Chem. 2014 May 16;289(20):13801-9. doi: 10.1074/jbc.M113.546929. Epub 2014 Apr 1. J Biol Chem. 2014. PMID: 24692540 Free PMC article.
Platelet integrin αIIbβ3 plays a key role in a venous thrombogenesis mouse model.
Adair BD, Field CO, Alonso JL, Xiong JP, Deng SX, Ahn HS, Mashin E, Clish CB, van Agthoven J, Yeager M, Guo Y, Tess DA, Landry DW, Poncz M, Arnaout MA. Adair BD, et al. Among authors: van agthoven j. Nat Commun. 2024 Oct 4;15(1):8612. doi: 10.1038/s41467-024-52869-3. Nat Commun. 2024. PMID: 39366965 Free PMC article.
Platelet integrin αIIbβ3 plays a key role in venous thrombogenesis in a mouse model.
Adair BD, Field CO, Alonso JL, Xiong JP, Deng SX, Ahn HS, Mashin E, Clish CB, van Agthoven J, Yeager M, Guo Y, Tess DA, Landry DW, Poncz M, Arnaout MA. Adair BD, et al. Among authors: van agthoven j. bioRxiv [Preprint]. 2024 Jul 16:2024.07.11.602533. doi: 10.1101/2024.07.11.602533. bioRxiv. 2024. Update in: Nat Commun. 2024 Oct 4;15(1):8612. doi: 10.1038/s41467-024-52869-3 PMID: 39026880 Free PMC article. Updated. Preprint.
GATA1 pathogenic variants disrupt MYH10 silencing during megakaryopoiesis.
Saultier P, Cabantous S, Puceat M, Peiretti F, Bigot T, Saut N, Bordet JC, Canault M, van Agthoven J, Loosveld M, Payet-Bornet D, Potier D, Falaise C, Bernot D, Morange PE, Alessi MC, Poggi M. Saultier P, et al. Among authors: van agthoven j. J Thromb Haemost. 2021 Sep;19(9):2287-2301. doi: 10.1111/jth.15412. Epub 2021 Jul 10. J Thromb Haemost. 2021. PMID: 34060193 Free article.
FLI1 and GATA1 govern TLN1 transcription: new insights into FLI1-related platelet disorders.
Gabinaud E, Hannouche L, Veneziano-Broccia M, Van Agthoven J, Suffit J, Maurizio J, Potier D, Payet-Bornet D, Bastelica D, Andersen E, Ibrahim-Kosta M, Bigot T, Falaise C; Hemostasis Unit of Lille; Vincenot A, Morange PE, Saultier P, Alessi MC, Poggi M. Gabinaud E, et al. Among authors: van agthoven j. Haematologica. 2025 Jan 2. doi: 10.3324/haematol.2024.286372. Online ahead of print. Haematologica. 2025. PMID: 39744817 Free article.
13 results