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Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer.
Fell JB, Fischer JP, Baer BR, Blake JF, Bouhana K, Briere DM, Brown KD, Burgess LE, Burns AC, Burkard MR, Chiang H, Chicarelli MJ, Cook AW, Gaudino JJ, Hallin J, Hanson L, Hartley DP, Hicken EJ, Hingorani GP, Hinklin RJ, Mejia MJ, Olson P, Otten JN, Rhodes SP, Rodriguez ME, Savechenkov P, Smith DJ, Sudhakar N, Sullivan FX, Tang TP, Vigers GP, Wollenberg L, Christensen JG, Marx MA. Fell JB, et al. Among authors: rodriguez me. J Med Chem. 2020 Jul 9;63(13):6679-6693. doi: 10.1021/acs.jmedchem.9b02052. Epub 2020 Apr 6. J Med Chem. 2020. PMID: 32250617 Free article.
Discovery of 5-Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors.
Elsayed MSA, Blake JF, Boys ML, Brown E, Chapsal BD, Chicarelli MJ, Cook AW, Fell JB, Fischer JP, Hanson L, Lemieux C, Martinson MC, McCown J, McNulty OT, Mejia MJ, Neitzel NA, Otten JN, Rodriguez ME, Wilcox D, Wong CE, Zhou Y, Hinklin RJ. Elsayed MSA, et al. Among authors: rodriguez me. ACS Med Chem Lett. 2023 Nov 15;14(12):1673-1681. doi: 10.1021/acsmedchemlett.3c00310. eCollection 2023 Dec 14. ACS Med Chem Lett. 2023. PMID: 38116446 Free PMC article.
Peripheral precocious puberty secondary to severe hypothyroidism.
Gil M, Martino F, Besseghine G, Rojas Ortiz MV, Rojas S, Rodríguez ME, Arcari A, Freire A. Gil M, et al. Among authors: rodriguez me. Arch Argent Pediatr. 2024 Nov 7:e202410456. doi: 10.5546/aap.2024-10456.eng. Online ahead of print. Arch Argent Pediatr. 2024. PMID: 39480725 Free article. English, Spanish.
Hypermigration of macrophages through the concerted action of GRA effectors on NF-κB/p38 signaling and host chromatin accessibility potentiates Toxoplasma dissemination.
Ten Hoeve AL, Rodriguez ME, Säflund M, Michel V, Magimel L, Ripoll A, Yu T, Hakimi M-A, Saeij JPJ, Ozata DM, Barragan A. Ten Hoeve AL, et al. Among authors: rodriguez me. mBio. 2024 Oct 16;15(10):e0214024. doi: 10.1128/mbio.02140-24. Epub 2024 Aug 29. mBio. 2024. PMID: 39207098 Free PMC article.
p38γ/δ activation alters cardiac electrical activity and predisposes to ventricular arrhythmia.
Romero-Becerra R, Cruz FM, Mora A, Lopez JA, Ponce-Balbuena D, Allan A, Ramos-Mondragón R, González-Terán B, León M, Rodríguez ME, Leiva-Vega L, Guerrero-Serna G, Jimenez-Vazquez EN, Filgueiras-Rama D, Vázquez J, Jalife J, Sabio G. Romero-Becerra R, et al. Among authors: rodriguez me. Nat Cardiovasc Res. 2023 Dec;2(12):1204-1220. doi: 10.1038/s44161-023-00368-x. Epub 2023 Nov 27. Nat Cardiovasc Res. 2023. PMID: 39196141
Nocturnal Salivary Cortisol Is an Accurate Non-Invasive Test to Assess Endogenous Hypercortisolism in Children with Obesity and a Clinical Phenotype Suspicious for Cushing's Syndrome.
Ballerini MG, Freire AV, Rodríguez ME, Brenzoni L, Daga L, Castro L, Arias Cau AC, Testa G, Gil M, Braslavsky D, Vieites A, Keselman A, Bergadá I, Arcari AJ, Ropelato MG. Ballerini MG, et al. Among authors: rodriguez me. Horm Res Paediatr. 2024 Aug 9:1-9. doi: 10.1159/000540785. Online ahead of print. Horm Res Paediatr. 2024. PMID: 39128457 Free article.
Real-world experience with mild-moderate COVID-19 therapies in kidney transplant patients: How to treat patients with chronic kidney disease from now on?
Alonso M, Villanego F, Vigara LA, Rodríguez ME, Eady M, García A, Mínguez MC, Montero ME, Segurado O, García T, Mazuecos A. Alonso M, et al. Among authors: rodriguez me. Nefrologia (Engl Ed). 2024 May-Jun;44(3):433-435. doi: 10.1016/j.nefroe.2024.06.003. Epub 2024 Jun 25. Nefrologia (Engl Ed). 2024. PMID: 38918164 Free article. No abstract available.
297 results