O'Mahony G - Search Results

1

PPARγ and PPARα synergize to induce robust browning of white fat in vivo.

Kroon T, Harms M, Maurer S, Bonnet L, Alexandersson I, Lindblom A, Ahnmark A, Nilsson D, Gennemark P, O'Mahony G, Osinski V, McNamara C, Boucher J. Kroon T, et al. Mol Metab. 2020 Jun;36:100964. doi: 10.1016/j.molmet.2020.02.007. Epub 2020 Feb 18. Mol Metab. 2020. PMID: 32248079 Free PMC article.

2

Unlock the Thermogenic Potential of Adipose Tissue: Pharmacological Modulation and Implications for Treatment of Diabetes and Obesity.

Peng XR, Gennemark P, O'Mahony G, Bartesaghi S. Peng XR, et al. Front Endocrinol (Lausanne). 2015 Nov 19;6:174. doi: 10.3389/fendo.2015.00174. eCollection 2015. Front Endocrinol (Lausanne). 2015. PMID: 26635723 Free PMC article. Review.

3

Importance of thorough tissue and cellular level characterization of targeted drugs in the evaluation of pharmacodynamic effects.

Bauknight DK, Osinski V, Dasa SSK, Nguyen AT, Marshall MA, Hartman J, Harms M, O'Mahony G, Boucher J, Klibanov AL, McNamara CA, Kelly KA. Bauknight DK, et al. PLoS One. 2019 Nov 14;14(11):e0224917. doi: 10.1371/journal.pone.0224917. eCollection 2019. PLoS One. 2019. PMID: 31725756 Free PMC article.

4

In vivo liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects.

Osinski V, Bauknight DK, Dasa SSK, Harms MJ, Kroon T, Marshall MA, Garmey JC, Nguyen AT, Hartman J, Upadhye A, Srikakulapu P, Zhou A, O'Mahony G, Klibanov AL, Kelly KA, Boucher J, McNamara CA. Osinski V, et al. Theranostics. 2020 Jan 1;10(2):585-601. doi: 10.7150/thno.36572. eCollection 2020. Theranostics. 2020. PMID: 31903139 Free PMC article.

5

A luminescence-based protocol for assessing fructose metabolism via quantification of ketohexokinase enzymatic activity in mouse or human hepatocytes.

Park SH, Helsley RN, Noetzli L, Tu HC, Wallenius K, O'Mahony G, Boucher J, Liu J, Softic S. Park SH, et al. Among authors: o mahony g. STAR Protoc. 2021 Aug 9;2(3):100731. doi: 10.1016/j.xpro.2021.100731. eCollection 2021 Sep 17. STAR Protoc. 2021. PMID: 34409309 Free PMC article.

6

Development of an ELISA for High-Throughput Screening of Inhibitors of Cdk5-Mediated PPARγ Phosphorylation.

Prokoph N, Ormö M, O'Mahony G, Hogner A, McPheat J, Karlsson U, Holmberg Schiavone L, Liu J. Prokoph N, et al. Assay Drug Dev Technol. 2016 May;14(4):261-72. doi: 10.1089/adt.2015.692. Epub 2016 Mar 30. Assay Drug Dev Technol. 2016. PMID: 27027223

7

Discovery by Virtual Screening of an Inhibitor of CDK5-Mediated PPARγ Phosphorylation.

O'Mahony G, Petersen J, Ek M, Rae R, Johansson C, Jianming L, Prokoph N, Bergström F, Bamberg K, Giordanetto F, Zarrouki B, Karlsson D, Hogner A. O'Mahony G, et al. ACS Med Chem Lett. 2022 Mar 11;13(4):681-686. doi: 10.1021/acsmedchemlett.1c00715. eCollection 2022 Apr 14. ACS Med Chem Lett. 2022. PMID: 35450368 Free PMC article.

8

Chronic treatment with terbutaline increases glucose and oleic acid oxidation and protein synthesis in cultured human myotubes.

Skagen C, Nyman TA, Peng XR, O'Mahony G, Kase ET, Rustan AC, Thoresen GH. Skagen C, et al. Among authors: o mahony g. Curr Res Pharmacol Drug Discov. 2021 Jun 11;2:100039. doi: 10.1016/j.crphar.2021.100039. eCollection 2021. Curr Res Pharmacol Drug Discov. 2021. PMID: 34909668 Free PMC article.

9

Discovery of N-(1-adamantyl)-2-(4-alkylpiperazin-1-yl)acetamide derivatives as T-type calcium channel (Cav3.2) inhibitors.

Giordanetto F, Knerr L, Selmi N, Llinàs A, Lindqvist A, Wang QD, Ståhlberg P, Thorstensson F, Ullah V, Nilsson K, O'Mahony G, Högberg G, Lindhardt E, Strand A, Duker G. Giordanetto F, et al. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5557-61. doi: 10.1016/j.bmcl.2011.06.092. Epub 2011 Jun 30. Bioorg Med Chem Lett. 2011. PMID: 21782423

10

Discovery of 4-hydroxy-1,6-naphthyridine-3-carbonitrile derivatives as novel PDE10A inhibitors.

Bauer U, Giordanetto F, Bauer M, O'Mahony G, Johansson KE, Knecht W, Hartleib-Geschwindner J, Carlsson ET, Enroth C. Bauer U, et al. Bioorg Med Chem Lett. 2012 Mar 1;22(5):1944-8. doi: 10.1016/j.bmcl.2012.01.046. Epub 2012 Jan 26. Bioorg Med Chem Lett. 2012. PMID: 22321214

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