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PPARγ and PPARα synergize to induce robust browning of white fat in vivo.
Kroon T, Harms M, Maurer S, Bonnet L, Alexandersson I, Lindblom A, Ahnmark A, Nilsson D, Gennemark P, O'Mahony G, Osinski V, McNamara C, Boucher J. Kroon T, et al. Mol Metab. 2020 Jun;36:100964. doi: 10.1016/j.molmet.2020.02.007. Epub 2020 Feb 18. Mol Metab. 2020. PMID: 32248079 Free PMC article.
In vivo liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects.
Osinski V, Bauknight DK, Dasa SSK, Harms MJ, Kroon T, Marshall MA, Garmey JC, Nguyen AT, Hartman J, Upadhye A, Srikakulapu P, Zhou A, O'Mahony G, Klibanov AL, Kelly KA, Boucher J, McNamara CA. Osinski V, et al. Among authors: kroon t. Theranostics. 2020 Jan 1;10(2):585-601. doi: 10.7150/thno.36572. eCollection 2020. Theranostics. 2020. PMID: 31903139 Free PMC article.
Cellular senescence in hepatocytes contributes to metabolic disturbances in NASH.
Bonnet L, Alexandersson I, Baboota RK, Kroon T, Oscarsson J, Smith U, Boucher J. Bonnet L, et al. Among authors: kroon t. Front Endocrinol (Lausanne). 2022 Aug 22;13:957616. doi: 10.3389/fendo.2022.957616. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36072934 Free PMC article.
Dosing profile profoundly influences nicotinic acid's ability to improve metabolic control in rats.
Kroon T, Kjellstedt A, Thalén P, Gabrielsson J, Oakes ND. Kroon T, et al. J Lipid Res. 2015 Sep;56(9):1679-90. doi: 10.1194/jlr.M058149. Epub 2015 Jul 13. J Lipid Res. 2015. PMID: 26168997 Free PMC article.
In conclusion, an intermittent but not continuous NiAc dosing strategy succeeded in retaining NiAc's ability to lower FFA and improve insulin sensitivity in obese Zucker rats.-Kroon, T., A. Kjellstedt, P. Thalen, J. Gabrielsson, and N. D. Oakes....
In conclusion, an intermittent but not continuous NiAc dosing strategy succeeded in retaining NiAc's ability to lower FFA and improve insuli …
76 results