Somanath PR - Search Results

1

PAK1 inhibitor IPA-3 mitigates metastatic prostate cancer-induced bone remodeling.

Verma A, Artham S, Alwhaibi A, Adil MS, Cummings BS, Somanath PR. Verma A, et al. Among authors: somanath pr. Biochem Pharmacol. 2020 Jul;177:113943. doi: 10.1016/j.bcp.2020.113943. Epub 2020 Mar 30. Biochem Pharmacol. 2020. PMID: 32240651 Free PMC article.

2

Anticancer efficacy of simvastatin on prostate cancer cells and tumor xenografts is associated with inhibition of Akt and reduced prostate-specific antigen expression.

Kochuparambil ST, Al-Husein B, Goc A, Soliman S, Somanath PR. Kochuparambil ST, et al. Among authors: somanath pr. J Pharmacol Exp Ther. 2011 Feb;336(2):496-505. doi: 10.1124/jpet.110.174870. Epub 2010 Nov 8. J Pharmacol Exp Ther. 2011. PMID: 21059805

3

Akt1 mediates prostate cancer cell microinvasion and chemotaxis to metastatic stimuli via integrin β₃ affinity modulation.

Goc A, Liu J, Byzova TV, Somanath PR. Goc A, et al. Among authors: somanath pr. Br J Cancer. 2012 Aug 7;107(4):713-23. doi: 10.1038/bjc.2012.295. Epub 2012 Jul 5. Br J Cancer. 2012. PMID: 22767145 Free PMC article.

4

Rac1 activation driven by 14-3-3ζ dimerization promotes prostate cancer cell-matrix interactions, motility and transendothelial migration.

Goc A, Abdalla M, Al-Azayzih A, Somanath PR. Goc A, et al. Among authors: somanath pr. PLoS One. 2012;7(7):e40594. doi: 10.1371/journal.pone.0040594. Epub 2012 Jul 13. PLoS One. 2012. PMID: 22808202 Free PMC article.

5

TGFβ1 induces apoptosis in invasive prostate cancer and bladder cancer cells via Akt-independent, p38 MAPK and JNK/SAPK-mediated activation of caspases.

Al-Azayzih A, Gao F, Goc A, Somanath PR. Al-Azayzih A, et al. Among authors: somanath pr. Biochem Biophys Res Commun. 2012 Oct 12;427(1):165-70. doi: 10.1016/j.bbrc.2012.09.035. Epub 2012 Sep 16. Biochem Biophys Res Commun. 2012. PMID: 22989755 Free PMC article.

6

P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion.

Goc A, Al-Azayzih A, Abdalla M, Al-Husein B, Kavuri S, Lee J, Moses K, Somanath PR. Goc A, et al. Among authors: somanath pr. J Biol Chem. 2013 Feb 1;288(5):3025-35. doi: 10.1074/jbc.M112.424770. Epub 2012 Dec 20. J Biol Chem. 2013. PMID: 23258534 Free PMC article.

7

Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo.

Goc A, Al-Husein B, Katsanevas K, Steinbach A, Lou U, Sabbineni H, DeRemer DL, Somanath PR. Goc A, et al. Among authors: somanath pr. Oncotarget. 2014 Feb 15;5(3):775-87. doi: 10.18632/oncotarget.1770. Oncotarget. 2014. PMID: 24519956 Free PMC article.

8

Clinically relevant doses of candesartan inhibit growth of prostate tumor xenografts in vivo through modulation of tumor angiogenesis.

Alhusban A, Al-Azayzih A, Goc A, Gao F, Fagan SC, Somanath PR. Alhusban A, et al. Among authors: somanath pr. J Pharmacol Exp Ther. 2014 Sep;350(3):635-45. doi: 10.1124/jpet.114.216382. Epub 2014 Jul 2. J Pharmacol Exp Ther. 2014. PMID: 24990940 Free PMC article.

9

P21 activated kinase-1 mediates transforming growth factor β1-induced prostate cancer cell epithelial to mesenchymal transition.

Al-Azayzih A, Gao F, Somanath PR. Al-Azayzih A, et al. Among authors: somanath pr. Biochim Biophys Acta. 2015 May;1853(5):1229-39. doi: 10.1016/j.bbamcr.2015.02.023. Epub 2015 Mar 6. Biochim Biophys Acta. 2015. PMID: 25746720 Free PMC article.

10

TNFα induces inflammatory stress response in microvascular endothelial cells via Akt- and P38 MAP kinase-mediated thrombospondin-1 expression.

Fairaq A, Goc A, Artham S, Sabbineni H, Somanath PR. Fairaq A, et al. Among authors: somanath pr. Mol Cell Biochem. 2015 Aug;406(1-2):227-36. doi: 10.1007/s11010-015-2440-0. Epub 2015 May 12. Mol Cell Biochem. 2015. PMID: 25963668 Free PMC article.

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