Topham CM - Search Results

1

Supracrystallographic resolution of interactions contributing to enzyme catalysis by use of natural structural variants and reactivity-probe kinetics.

Brocklehurst K, Brocklehurst SM, Kowlessur D, O'Driscoll M, Patel G, Salih E, Templeton W, Thomas E, Topham CM, Willenbrock F. Brocklehurst K, et al. Among authors: topham cm. Biochem J. 1988 Dec 1;256(2):543-58. doi: 10.1042/bj2560543. Biochem J. 1988. PMID: 3223929 Free PMC article.

2

In defence of the general validity of the Cha method of deriving rate equations. The importance of explicit recognition of the thermodynamic box in enzyme kinetics.

Topham CM, Brocklehurst K. Topham CM, et al. Biochem J. 1992 Feb 15;282 ( Pt 1)(Pt 1):261-5. doi: 10.1042/bj2820261. Biochem J. 1992. PMID: 1540141 Free PMC article.

3

Structure-function relationships in the cysteine proteinases actinidin, papain and papaya proteinase omega. Three-dimensional structure of papaya proteinase omega deduced by knowledge-based modelling and active-centre characteristics determined by two-hydronic-state reactivity probe kinetics and kinetics of catalysis.

Topham CM, Salih E, Frazao C, Kowlessur D, Overington JP, Thomas M, Brocklehurst SM, Patel M, Thomas EW, Brocklehurst K. Topham CM, et al. Biochem J. 1991 Nov 15;280 ( Pt 1)(Pt 1):79-92. doi: 10.1042/bj2800079. Biochem J. 1991. PMID: 1741760 Free PMC article.

4

Three-dimensional structure and thiol reactivity characteristics of chymopapain M (papaya proteinase IV).

Topham CM, Overington J, Thomas M, Kowlessur D, Thomas EW, Brocklehurst K. Topham CM, et al. Biochem Soc Trans. 1990 Oct;18(5):934-5. doi: 10.1042/bst0180934. Biochem Soc Trans. 1990. PMID: 2083746 No abstract available.

5

Investigation of mechanistic consequences of natural structural variation within the cysteine proteinases by knowledge-based modelling and kinetic methods.

Topham CM, Overington J, Kowlessur D, Thomas M, Thomas EW, Brocklehurst K. Topham CM, et al. Biochem Soc Trans. 1990 Aug;18(4):579-80. doi: 10.1042/bst0180579. Biochem Soc Trans. 1990. PMID: 2276446 No abstract available.

6

A general kinetic equation for multihydronic state reactions and rapid procedures for parameter evaluation.

Brocklehurst SM, Topham CM, Brocklehurst K. Brocklehurst SM, et al. Among authors: topham cm. Biochem Soc Trans. 1990 Aug;18(4):598-600. doi: 10.1042/bst0180598. Biochem Soc Trans. 1990. PMID: 2276457 No abstract available.

7

A re-appraisal of the structural basis of stereochemical recognition in papain. Insensitivity of binding-site-catalytic-site signalling to P2-chirality in a time-dependent inhibition.

Templeton W, Kowlessur D, Thomas EW, Topham CM, Brocklehurst K. Templeton W, et al. Among authors: topham cm. Biochem J. 1990 Mar 15;266(3):645-51. doi: 10.1042/bj2660645. Biochem J. 1990. PMID: 2327953 Free PMC article.

8

Dependence of the P2-S2 stereochemical selectivity of papain on the nature of the catalytic-site chemistry. Quantification of selectivity in the catalysed hydrolysis of the enantiomeric N-acetylphenylalanylglycine 4-nitroanilides.

Kowlessur D, Thomas EW, Topham CM, Templeton W, Brocklehurst K. Kowlessur D, et al. Among authors: topham cm. Biochem J. 1990 Mar 15;266(3):653-60. doi: 10.1042/bj2660653. Biochem J. 1990. PMID: 2327954 Free PMC article.

9

Kinetic parameters of the acyl-enzyme mechanism and conditions for quasi-equilibrium and for optimal catalytic characteristics.

Brocklehurst K, Topham CM. Brocklehurst K, et al. Among authors: topham cm. Biochem J. 1990 Sep 1;270(2):561-3. doi: 10.1042/bj2700561. Biochem J. 1990. PMID: 2400403 Free PMC article. No abstract available.

10

The interplay of electrostatic fields and binding interactions determining catalytic-site reactivity in actinidin. A possible origin of differences in the behaviour of actinidin and papain.

Kowlessur D, O'Driscoll M, Topham CM, Templeton W, Thomas EW, Brocklehurst K. Kowlessur D, et al. Among authors: topham cm. Biochem J. 1989 Apr 15;259(2):443-52. doi: 10.1042/bj2590443. Biochem J. 1989. PMID: 2719659 Free PMC article.

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