Templeton W - Search Results

1

Supracrystallographic resolution of interactions contributing to enzyme catalysis by use of natural structural variants and reactivity-probe kinetics.

Brocklehurst K, Brocklehurst SM, Kowlessur D, O'Driscoll M, Patel G, Salih E, Templeton W, Thomas E, Topham CM, Willenbrock F. Brocklehurst K, et al. Among authors: templeton w. Biochem J. 1988 Dec 1;256(2):543-58. doi: 10.1042/bj2560543. Biochem J. 1988. PMID: 3223929 Free PMC article.

2

Evaluation of hydrogen-bonding and enantiomeric P2-S2 hydrophobic contacts in dynamic aspects of molecular recognition by papain.

Patel M, Kayani IS, Templeton W, Mellor GW, Thomas EW, Brocklehurst K. Patel M, et al. Among authors: templeton w. Biochem J. 1992 Nov 1;287 ( Pt 3)(Pt 3):881-9. doi: 10.1042/bj2870881. Biochem J. 1992. PMID: 1445247 Free PMC article.

3

Variation in the P2-S2 stereochemical selectivity towards the enantiomeric N-acetylphenylalanylglycine 4-nitroanilides among the cysteine proteinases papain, ficin and actinidin.

Patel M, Kayani IS, Mellor GW, Sreedharan S, Templeton W, Thomas EW, Thomas M, Brocklehurst K. Patel M, et al. Among authors: templeton w. Biochem J. 1992 Jan 15;281 ( Pt 2)(Pt 2):553-9. doi: 10.1042/bj2810553. Biochem J. 1992. PMID: 1736903 Free PMC article.

4

Dynamic aspects of molecular recognition in cysteine proteinase-ligand systems.

Brocklehurst K, Thomas EW, Quenby S, Kowlessur D, Gooding C, Templeton W, Wilkie E, Patel M, Sreedharan S, Thomas M, et al. Brocklehurst K, et al. Among authors: templeton w. Biochem Soc Trans. 1990 Aug;18(4):581-2. doi: 10.1042/bst0180581. Biochem Soc Trans. 1990. PMID: 2276447 No abstract available.

5

A re-appraisal of the structural basis of stereochemical recognition in papain. Insensitivity of binding-site-catalytic-site signalling to P2-chirality in a time-dependent inhibition.

Templeton W, Kowlessur D, Thomas EW, Topham CM, Brocklehurst K. Templeton W, et al. Biochem J. 1990 Mar 15;266(3):645-51. doi: 10.1042/bj2660645. Biochem J. 1990. PMID: 2327953 Free PMC article.

6

Dependence of the P2-S2 stereochemical selectivity of papain on the nature of the catalytic-site chemistry. Quantification of selectivity in the catalysed hydrolysis of the enantiomeric N-acetylphenylalanylglycine 4-nitroanilides.

Kowlessur D, Thomas EW, Topham CM, Templeton W, Brocklehurst K. Kowlessur D, et al. Among authors: templeton w. Biochem J. 1990 Mar 15;266(3):653-60. doi: 10.1042/bj2660653. Biochem J. 1990. PMID: 2327954 Free PMC article.

7

The interplay of electrostatic fields and binding interactions determining catalytic-site reactivity in actinidin. A possible origin of differences in the behaviour of actinidin and papain.

Kowlessur D, O'Driscoll M, Topham CM, Templeton W, Thomas EW, Brocklehurst K. Kowlessur D, et al. Among authors: templeton w. Biochem J. 1989 Apr 15;259(2):443-52. doi: 10.1042/bj2590443. Biochem J. 1989. PMID: 2719659 Free PMC article.

8

Identification of signalling and non-signalling binding contributions to enzyme reactivity. Alternative combinations of binding interactions provide for change in transition-state geometry in reactions of papain.

Kowlessur D, Topham CM, Thomas EW, O'Driscoll M, Templeton W, Brocklehurst K. Kowlessur D, et al. Among authors: templeton w. Biochem J. 1989 Mar 15;258(3):755-64. doi: 10.1042/bj2580755. Biochem J. 1989. PMID: 2730566 Free PMC article.

9

Consequences of molecular recognition in the S1-S2 intersubsite region of papain for catalytic-site chemistry. Change in pH-dependence characteristics and generation of an inverse solvent kinetic isotope effect by introduction of a P1-P2 amide bond into a two-protonic-state reactivity probe.

Brocklehurst K, Kowlessur D, Patel G, Templeton W, Quigley K, Thomas EW, Wharton CW, Willenbrock F, Szawelski RJ. Brocklehurst K, et al. Among authors: templeton w. Biochem J. 1988 Mar 15;250(3):761-72. doi: 10.1042/bj2500761. Biochem J. 1988. PMID: 2839145 Free PMC article.

10

The interplay of electrostatic and binding interactions determining active centre chemistry and catalytic activity in actinidin and papain.

Brocklehurst K, O'Driscoll M, Kowlessur D, Phillips IR, Templeton W, Thomas EW, Topham CM, Wharton CW. Brocklehurst K, et al. Among authors: templeton w. Biochem J. 1989 Jan 1;257(1):309-10. doi: 10.1042/bj2570309. Biochem J. 1989. PMID: 2920023 Free PMC article. No abstract available.

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