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Page 1
Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood.
Weeks O, Bossé GD, Oderberg IM, Akle S, Houvras Y, Wrighton PJ, LaBella K, Iversen I, Tavakoli S, Adatto I, Schwartz A, Kloosterman D, Tsomides A, Charness ME, Peterson RT, Steinhauser ML, Fazeli PK, Goessling W. Weeks O, et al. Among authors: kloosterman d. J Clin Invest. 2020 May 1;130(5):2252-2269. doi: 10.1172/JCI132139. J Clin Invest. 2020. PMID: 32202514 Free PMC article.
Glioblastoma scRNA-seq shows treatment-induced, immune-dependent increase in mesenchymal cancer cells and structural variants in distal neural stem cells.
Couturier CP, Nadaf J, Li Z, Baig S, Riva G, Le P, Kloosterman DJ, Monlong J, Nkili Meyong A, Allache R, Degenhard T, Al-Rashid M, Guiot MC, Bourque G, Ragoussis J, Akkari L, Quintana FJ, Petrecca K. Couturier CP, et al. Among authors: kloosterman dj. Neuro Oncol. 2022 Sep 1;24(9):1494-1508. doi: 10.1093/neuonc/noac085. Neuro Oncol. 2022. PMID: 35416251 Free PMC article.
Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of Diffuse Large B-cell Lymphoma.
Göbel C, Niccolai R, de Groot MHP, Jayachandran J, Traets J, Kloosterman DJ, Gregoricchio S, Morris B, Kreft M, Song JY, Azarang L, Kasa E, Oskam N, de Groot D, Hoekman L, Bleijerveld O, Kersten MJ, Aslam MA, Leeuwen FV, Jacobs H. Göbel C, et al. Among authors: kloosterman dj. Blood. 2025 Jan 10:blood.2024025500. doi: 10.1182/blood.2024025500. Online ahead of print. Blood. 2025. PMID: 39792929
Macrophage-mediated myelin recycling fuels brain cancer malignancy.
Kloosterman DJ, Erbani J, Boon M, Farber M, Handgraaf SM, Ando-Kuri M, Sánchez-López E, Fontein B, Mertz M, Nieuwland M, Liu NQ, Forn-Cuni G, van der Wel NN, Grootemaat AE, Reinalda L, van Kasteren SI, de Wit E, Ruffell B, Snaar-Jagalska E, Petrecca K, Brandsma D, Kros A, Giera M, Akkari L. Kloosterman DJ, et al. Cell. 2024 Sep 19;187(19):5336-5356.e30. doi: 10.1016/j.cell.2024.07.030. Epub 2024 Aug 12. Cell. 2024. PMID: 39137777 Free PMC article.
Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma.
Ramirez CFA, Taranto D, Ando-Kuri M, de Groot MHP, Tsouri E, Huang Z, de Groot D, Kluin RJC, Kloosterman DJ, Verheij J, Xu J, Vegna S, Akkari L. Ramirez CFA, et al. Among authors: kloosterman dj. Nat Commun. 2024 Mar 22;15(1):2581. doi: 10.1038/s41467-024-46835-2. Nat Commun. 2024. PMID: 38519484 Free PMC article.
CD103+ regulatory T cells underlie resistance to radio-immunotherapy and impair CD8+ T cell activation in glioblastoma.
van Hooren L, Handgraaf SM, Kloosterman DJ, Karimi E, van Mil LWHG, Gassama AA, Solsona BG, de Groot MHP, Brandsma D, Quail DF, Walsh LA, Borst GR, Akkari L. van Hooren L, et al. Among authors: kloosterman dj. Nat Cancer. 2023 May;4(5):665-681. doi: 10.1038/s43018-023-00547-6. Epub 2023 Apr 20. Nat Cancer. 2023. PMID: 37081259 Free PMC article.
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