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Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction.
Bautista-Niño PK, Portilla-Fernandez E, Rubio-Beltrán E, van der Linden JJ, de Vries R, van Veghel R, de Boer M, Durik M, Ridwan Y, Brandt R, Essers J, Menzies RI, Thomas R, de Bruin A, Duncker DJ, van Beusekom HMM, Ghanbari M, Hoeijmakers JHJ, Sedlacek R, Touyz RM, Montezano AC, van der Pluijm I, Danser AHJ, Haanes KA, Roks AJM. Bautista-Niño PK, et al. Among authors: brandt r. Clin Sci (Lond). 2020 Apr 17;134(7):727-746. doi: 10.1042/CS20190124. Clin Sci (Lond). 2020. PMID: 32202295 Free article.
Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome.
van der Pluijm I, Garinis GA, Brandt RM, Gorgels TG, Wijnhoven SW, Diderich KE, de Wit J, Mitchell JR, van Oostrom C, Beems R, Niedernhofer LJ, Velasco S, Friedberg EC, Tanaka K, van Steeg H, Hoeijmakers JH, van der Horst GT. van der Pluijm I, et al. Among authors: brandt rm. PLoS Biol. 2007 Jan;5(1):e2. doi: 10.1371/journal.pbio.0050002. PLoS Biol. 2007. PMID: 17326724 Free PMC article.
Age-related neuronal degeneration: complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology.
Jaarsma D, van der Pluijm I, de Waard MC, Haasdijk ED, Brandt R, Vermeij M, Rijksen Y, Maas A, van Steeg H, Hoeijmakers JH, van der Horst GT. Jaarsma D, et al. Among authors: brandt r. PLoS Genet. 2011 Dec;7(12):e1002405. doi: 10.1371/journal.pgen.1002405. Epub 2011 Dec 8. PLoS Genet. 2011. PMID: 22174697 Free PMC article.
Nucleotide excision DNA repair is associated with age-related vascular dysfunction.
Durik M, Kavousi M, van der Pluijm I, Isaacs A, Cheng C, Verdonk K, Loot AE, Oeseburg H, Bhaggoe UM, Leijten F, van Veghel R, de Vries R, Rudez G, Brandt R, Ridwan YR, van Deel ED, de Boer M, Tempel D, Fleming I, Mitchell GF, Verwoert GC, Tarasov KV, Uitterlinden AG, Hofman A, Duckers HJ, van Duijn CM, Oostra BA, Witteman JC, Duncker DJ, Danser AH, Hoeijmakers JH, Roks AJ. Durik M, et al. Among authors: brandt r. Circulation. 2012 Jul 24;126(4):468-78. doi: 10.1161/CIRCULATIONAHA.112.104380. Epub 2012 Jun 15. Circulation. 2012. PMID: 22705887 Free PMC article.
Priming of microglia in a DNA-repair deficient model of accelerated aging.
Raj DD, Jaarsma D, Holtman IR, Olah M, Ferreira FM, Schaafsma W, Brouwer N, Meijer MM, de Waard MC, van der Pluijm I, Brandt R, Kreft KL, Laman JD, de Haan G, Biber KP, Hoeijmakers JH, Eggen BJ, Boddeke HW. Raj DD, et al. Among authors: brandt r. Neurobiol Aging. 2014 Sep;35(9):2147-60. doi: 10.1016/j.neurobiolaging.2014.03.025. Epub 2014 Mar 28. Neurobiol Aging. 2014. PMID: 24799273 Free article.
Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency.
Barnhoorn S, Uittenboogaard LM, Jaarsma D, Vermeij WP, Tresini M, Weymaere M, Menoni H, Brandt RM, de Waard MC, Botter SM, Sarker AH, Jaspers NG, van der Horst GT, Cooper PK, Hoeijmakers JH, van der Pluijm I. Barnhoorn S, et al. PLoS Genet. 2014 Oct 9;10(10):e1004686. doi: 10.1371/journal.pgen.1004686. eCollection 2014 Oct. PLoS Genet. 2014. PMID: 25299392 Free PMC article.
799 results