Mpakali A - Search Results

1

A systematic re-examination of processing of MHCI-bound antigenic peptide precursors by endoplasmic reticulum aminopeptidase 1.

Mavridis G, Arya R, Domnick A, Zoidakis J, Makridakis M, Vlahou A, Mpakali A, Lelis A, Georgiadis D, Tampé R, Papakyriakou A, Stern LJ, Stratikos E. Mavridis G, et al. Among authors: mpakali a. J Biol Chem. 2020 May 22;295(21):7193-7210. doi: 10.1074/jbc.RA120.012976. Epub 2020 Mar 17. J Biol Chem. 2020. PMID: 32184355 Free PMC article.

2

Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing.

Mpakali A, Saridakis E, Harlos K, Zhao Y, Papakyriakou A, Kokkala P, Georgiadis D, Stratikos E. Mpakali A, et al. J Immunol. 2015 Sep 15;195(6):2842-51. doi: 10.4049/jimmunol.1501103. Epub 2015 Aug 10. J Immunol. 2015. PMID: 26259583

3

Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2.

Mpakali A, Giastas P, Mathioudakis N, Mavridis IM, Saridakis E, Stratikos E. Mpakali A, et al. J Biol Chem. 2015 Oct 23;290(43):26021-32. doi: 10.1074/jbc.M115.685909. Epub 2015 Sep 17. J Biol Chem. 2015. PMID: 26381406 Free PMC article.

4

Optimization and Structure-Activity Relationships of Phosphinic Pseudotripeptide Inhibitors of Aminopeptidases That Generate Antigenic Peptides.

Kokkala P, Mpakali A, Mauvais FX, Papakyriakou A, Daskalaki I, Petropoulou I, Kavvalou S, Papathanasopoulou M, Agrotis S, Fonsou TM, van Endert P, Stratikos E, Georgiadis D. Kokkala P, et al. Among authors: mpakali a. J Med Chem. 2016 Oct 13;59(19):9107-9123. doi: 10.1021/acs.jmedchem.6b01031. Epub 2016 Sep 20. J Med Chem. 2016. PMID: 27606717

5

Critical Role of Interdomain Interactions in the Conformational Change and Catalytic Mechanism of Endoplasmic Reticulum Aminopeptidase 1.

Stamogiannos A, Maben Z, Papakyriakou A, Mpakali A, Kokkala P, Georgiadis D, Stern LJ, Stratikos E. Stamogiannos A, et al. Among authors: mpakali a. Biochemistry. 2017 Mar 14;56(10):1546-1558. doi: 10.1021/acs.biochem.6b01170. Epub 2017 Mar 2. Biochemistry. 2017. PMID: 28218509 Free PMC article.

6

Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.

Mpakali A, Saridakis E, Harlos K, Zhao Y, Kokkala P, Georgiadis D, Giastas P, Papakyriakou A, Stratikos E. Mpakali A, et al. J Med Chem. 2017 Apr 13;60(7):2963-2972. doi: 10.1021/acs.jmedchem.6b01890. Epub 2017 Apr 3. J Med Chem. 2017. PMID: 28328206

7

Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency.

Mpakali A, Giastas P, Deprez-Poulain R, Papakyriakou A, Koumantou D, Gealageas R, Tsoukalidou S, Vourloumis D, Mavridis IM, Stratikos E, Saridakis E. Mpakali A, et al. ACS Med Chem Lett. 2017 Feb 21;8(3):333-337. doi: 10.1021/acsmedchemlett.6b00505. eCollection 2017 Mar 9. ACS Med Chem Lett. 2017. PMID: 28337326 Free PMC article.

8

Inhibitors of ER Aminopeptidase 1 and 2: From Design to Clinical Application.

Georgiadis D, Mpakali A, Koumantou D, Stratikos E. Georgiadis D, et al. Among authors: mpakali a. Curr Med Chem. 2019;26(15):2715-2729. doi: 10.2174/0929867325666180214111849. Curr Med Chem. 2019. PMID: 29446724 Review.

9

Molecular pathways for antigenic peptide generation by ER aminopeptidase 1.

Mpakali A, Maben Z, Stern LJ, Stratikos E. Mpakali A, et al. Mol Immunol. 2019 Sep;113:50-57. doi: 10.1016/j.molimm.2018.03.026. Epub 2018 Apr 17. Mol Immunol. 2019. PMID: 29678301 Free PMC article. Review.

10

Endoplasmic reticulum aminopeptidase 1 polymorphism Ile276Met is associated with atopic dermatitis and affects the generation of an HLA-C associated antigenic epitope in vitro.

Niepiekło-Miniewska W, Mpakali A, Stratikos E, Matusiak Ł, Narbutt J, Lesiak A, Kuna P, Wilczyńska K, Nowak I, Wiśniewski A, Zwolińska K, Ponińska J, Płoski R, Szepietowski JC, Kuśnierczyk P. Niepiekło-Miniewska W, et al. Among authors: mpakali a. J Eur Acad Dermatol Venereol. 2019 May;33(5):906-911. doi: 10.1111/jdv.15449. Epub 2019 Mar 4. J Eur Acad Dermatol Venereol. 2019. PMID: 30680818

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