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Page 1
A persistent variant telomere sequence in a human pedigree.
Hinchie AM, Sanford SL, Loughridge KE, Sutton RM, Parikh AH, Gil Silva AA, Sullivan DI, Chun-On P, Morrell MR, McDyer JF, Opresko PL, Alder JK. Hinchie AM, et al. Among authors: opresko pl. Nat Commun. 2024 Jun 1;15(1):4681. doi: 10.1038/s41467-024-49072-9. Nat Commun. 2024. PMID: 38824190 Free PMC article.
Co-regulator activity of Mediator of DNA Damage Checkpoint 1 (MDC1) is associated with DNA repair dysfunction and PARP inhibitor sensitivity in lobular carcinoma of the breast.
Sottnik JL, Shackleford MT, Nesiba CS, Richer AL, Swartz JM, Rowland CE, Musick M, Fu R, Opresko PL, Mehrotra S, Hesselberth JR, Diamond JR, Sikora MJ. Sottnik JL, et al. Among authors: opresko pl. bioRxiv [Preprint]. 2024 Dec 6:2023.10.29.564555. doi: 10.1101/2023.10.29.564555. bioRxiv. 2024. PMID: 39677775 Free PMC article. Preprint.
Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging.
Robinson AR, Yousefzadeh MJ, Rozgaja TA, Wang J, Li X, Tilstra JS, Feldman CH, Gregg SQ, Johnson CH, Skoda EM, Frantz MC, Bell-Temin H, Pope-Varsalona H, Gurkar AU, Nasto LA, Robinson RAS, Fuhrmann-Stroissnigg H, Czerwinska J, McGowan SJ, Cantu-Medellin N, Harris JB, Maniar S, Ross MA, Trussoni CE, LaRusso NF, Cifuentes-Pagano E, Pagano PJ, Tudek B, Vo NV, Rigatti LH, Opresko PL, Stolz DB, Watkins SC, Burd CE, Croix CMS, Siuzdak G, Yates NA, Robbins PD, Wang Y, Wipf P, Kelley EE, Niedernhofer LJ. Robinson AR, et al. Among authors: opresko pl. Redox Biol. 2018 Jul;17:259-273. doi: 10.1016/j.redox.2018.04.007. Epub 2018 Apr 13. Redox Biol. 2018. PMID: 29747066 Free PMC article.
Damage sensor role of UV-DDB during base excision repair.
Jang S, Kumar N, Beckwitt EC, Kong M, Fouquerel E, Rapić-Otrin V, Prasad R, Watkins SC, Khuu C, Majumdar C, David SS, Wilson SH, Bruchez MP, Opresko PL, Van Houten B. Jang S, et al. Among authors: opresko pl. Nat Struct Mol Biol. 2019 Aug;26(8):695-703. doi: 10.1038/s41594-019-0261-7. Epub 2019 Jul 22. Nat Struct Mol Biol. 2019. PMID: 31332353 Free PMC article.
Chemoptogenetic damage to mitochondria causes rapid telomere dysfunction.
Qian W, Kumar N, Roginskaya V, Fouquerel E, Opresko PL, Shiva S, Watkins SC, Kolodieznyi D, Bruchez MP, Van Houten B. Qian W, et al. Among authors: opresko pl. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18435-18444. doi: 10.1073/pnas.1910574116. Epub 2019 Aug 26. Proc Natl Acad Sci U S A. 2019. PMID: 31451640 Free PMC article.
Mechanisms of nucleotide selection by telomerase.
Schaich MA, Sanford SL, Welfer GA, Johnson SA, Khoang TH, Opresko PL, Freudenthal BD. Schaich MA, et al. Among authors: opresko pl. Elife. 2020 Jun 5;9:e55438. doi: 10.7554/eLife.55438. Elife. 2020. PMID: 32501800 Free PMC article.
107 results