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The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1G93A mice.
Ly D, Dongol A, Cuthbertson P, Guy TV, Geraghty NJ, Sophocleous RA, Sin L, Turner BJ, Watson D, Yerbury JJ, Sluyter R. Ly D, et al. Among authors: yerbury jj. Purinergic Signal. 2020 Mar;16(1):109-122. doi: 10.1007/s11302-020-09692-4. Epub 2020 Mar 13. Purinergic Signal. 2020. PMID: 32170537 Free PMC article.
Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms.
Grad LI, Yerbury JJ, Turner BJ, Guest WC, Pokrishevsky E, O'Neill MA, Yanai A, Silverman JM, Zeineddine R, Corcoran L, Kumita JR, Luheshi LM, Yousefi M, Coleman BM, Hill AF, Plotkin SS, Mackenzie IR, Cashman NR. Grad LI, et al. Among authors: yerbury jj. Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3620-5. doi: 10.1073/pnas.1312245111. Epub 2014 Feb 18. Proc Natl Acad Sci U S A. 2014. PMID: 24550511 Free PMC article.
SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation.
Zeineddine R, Pundavela JF, Corcoran L, Stewart EM, Do-Ha D, Bax M, Guillemin G, Vine KL, Hatters DM, Ecroyd H, Dobson CM, Turner BJ, Ooi L, Wilson MR, Cashman NR, Yerbury JJ. Zeineddine R, et al. Among authors: yerbury jj. Mol Neurodegener. 2015 Oct 31;10:57. doi: 10.1186/s13024-015-0053-4. Mol Neurodegener. 2015. PMID: 26520394 Free PMC article.
P2X7 receptor antagonism in amyotrophic lateral sclerosis.
Sluyter R, Bartlett R, Ly D, Yerbury JJ. Sluyter R, et al. Among authors: yerbury jj. Neural Regen Res. 2017 May;12(5):749-750. doi: 10.4103/1673-5374.206643. Neural Regen Res. 2017. PMID: 28616029 Free PMC article. No abstract available.
98 results