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Page 1
Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation.
De Rossi P, Nomura T, Andrew RJ, Masse NY, Sampathkumar V, Musial TF, Sudwarts A, Recupero AJ, Le Metayer T, Hansen MT, Shim HN, Krause SV, Freedman DJ, Bindokas VP, Kasthuri N, Nicholson DA, Contractor A, Thinakaran G. De Rossi P, et al. Among authors: thinakaran g. Cell Rep. 2020 Mar 10;30(10):3520-3535.e7. doi: 10.1016/j.celrep.2020.02.026. Cell Rep. 2020. PMID: 32160554 Free PMC article.
Predominant expression of Alzheimer's disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts.
De Rossi P, Buggia-Prévot V, Clayton BL, Vasquez JB, van Sanford C, Andrew RJ, Lesnick R, Botté A, Deyts C, Salem S, Rao E, Rice RC, Parent A, Kar S, Popko B, Pytel P, Estus S, Thinakaran G. De Rossi P, et al. Among authors: thinakaran g. Mol Neurodegener. 2016 Aug 3;11(1):59. doi: 10.1186/s13024-016-0124-1. Mol Neurodegener. 2016. PMID: 27488240 Free PMC article.
Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease.
Andrew RJ, Fernandez CG, Stanley M, Jiang H, Nguyen P, Rice RC, Buggia-Prévot V, De Rossi P, Vetrivel KS, Lamb R, Argemi A, Allaert ES, Rathbun EM, Krause SV, Wagner SL, Parent AT, Holtzman DM, Thinakaran G. Andrew RJ, et al. Among authors: thinakaran g. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9665-E9674. doi: 10.1073/pnas.1708568114. Epub 2017 Oct 23. Proc Natl Acad Sci U S A. 2017. PMID: 29078331 Free PMC article.
BIN1 localization is distinct from Tau tangles in Alzheimer's disease.
De Rossi P, Buggia-Prevot V, Andrew RJ, Krause SV, Woo E, Nelson PT, Pytel P, Thinakaran G. De Rossi P, et al. Among authors: thinakaran g. Matters (Zur). 2017 Jan;2017:10.19185/matters.201611000018. doi: 10.19185/matters.201611000018. Epub 2017 Jan 12. Matters (Zur). 2017. PMID: 29479533 Free PMC article.
Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models.
De Rossi P, Andrew RJ, Musial TF, Buggia-Prevot V, Xu G, Ponnusamy M, Ly H, Krause SV, Rice RC, de l'Estoile V, Valin T, Salem S, Despa F, Borchelt DR, Bindokas VP, Nicholson DA, Thinakaran G. De Rossi P, et al. Among authors: thinakaran g. Brain Pathol. 2019 Jul;29(4):485-501. doi: 10.1111/bpa.12687. Epub 2018 Dec 27. Brain Pathol. 2019. PMID: 30506549 Free PMC article.
Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model.
Andrew RJ, De Rossi P, Nguyen P, Kowalski HR, Recupero AJ, Guerbette T, Krause SV, Rice RC, Laury-Kleintop L, Wagner SL, Thinakaran G. Andrew RJ, et al. Among authors: thinakaran g. J Biol Chem. 2019 Mar 22;294(12):4477-4487. doi: 10.1074/jbc.RA118.006379. Epub 2019 Jan 28. J Biol Chem. 2019. PMID: 30692199 Free PMC article.
BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia.
Sudwarts A, Ramesha S, Gao T, Ponnusamy M, Wang S, Hansen M, Kozlova A, Bitarafan S, Kumar P, Beaulieu-Abdelahad D, Zhang X, Collier L, Szekeres C, Wood LB, Duan J, Thinakaran G, Rangaraju S. Sudwarts A, et al. Among authors: thinakaran g. Mol Neurodegener. 2022 May 7;17(1):33. doi: 10.1186/s13024-022-00535-x. Mol Neurodegener. 2022. PMID: 35526014 Free PMC article.
138 results