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Page 1
A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors.
Nemet I, Saha PP, Gupta N, Zhu W, Romano KA, Skye SM, Cajka T, Mohan ML, Li L, Wu Y, Funabashi M, Ramer-Tait AE, Naga Prasad SV, Fiehn O, Rey FE, Tang WHW, Fischbach MA, DiDonato JA, Hazen SL. Nemet I, et al. Among authors: skye sm. Cell. 2020 Mar 5;180(5):862-877.e22. doi: 10.1016/j.cell.2020.02.016. Cell. 2020. PMID: 32142679 Free PMC article.
The microbial gbu gene cluster links cardiovascular disease risk associated with red meat consumption to microbiota L-carnitine catabolism.
Buffa JA, Romano KA, Copeland MF, Cody DB, Zhu W, Galvez R, Fu X, Ward K, Ferrell M, Dai HJ, Skye S, Hu P, Li L, Parlov M, McMillan A, Wei X, Nemet I, Koeth RA, Li XS, Wang Z, Sangwan N, Hajjar AM, Dwidar M, Weeks TL, Bergeron N, Krauss RM, Tang WHW, Rey FE, DiDonato JA, Gogonea V, Gerberick GF, Garcia-Garcia JC, Hazen SL. Buffa JA, et al. Nat Microbiol. 2022 Jan;7(1):73-86. doi: 10.1038/s41564-021-01010-x. Epub 2021 Dec 23. Nat Microbiol. 2022. PMID: 34949826 Free PMC article.
Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk.
Li XS, Wang Z, Cajka T, Buffa JA, Nemet I, Hurd AG, Gu X, Skye SM, Roberts AB, Wu Y, Li L, Shahen CJ, Wagner MA, Hartiala JA, Kerby RL, Romano KA, Han Y, Obeid S, Lüscher TF, Allayee H, Rey FE, DiDonato JA, Fiehn O, Tang WHW, Hazen SL. Li XS, et al. Among authors: skye sm. JCI Insight. 2018 Mar 22;3(6):e99096. doi: 10.1172/jci.insight.99096. JCI Insight. 2018. PMID: 29563342 Free PMC article.
Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease.
Gupta N, Buffa JA, Roberts AB, Sangwan N, Skye SM, Li L, Ho KJ, Varga J, DiDonato JA, Tang WHW, Hazen SL. Gupta N, et al. Among authors: skye sm. Arterioscler Thromb Vasc Biol. 2020 May;40(5):1239-1255. doi: 10.1161/ATVBAHA.120.314139. Epub 2020 Mar 26. Arterioscler Thromb Vasc Biol. 2020. PMID: 32212854 Free PMC article.
Microbial Modulation of a Uremic Toxin.
Skye SM, Hazen SL. Skye SM, et al. Cell Host Microbe. 2016 Dec 14;20(6):691-692. doi: 10.1016/j.chom.2016.11.005. Cell Host Microbe. 2016. PMID: 27978427 Free article.
Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential.
Roberts AB, Gu X, Buffa JA, Hurd AG, Wang Z, Zhu W, Gupta N, Skye SM, Cody DB, Levison BS, Barrington WT, Russell MW, Reed JM, Duzan A, Lang JM, Fu X, Li L, Myers AJ, Rachakonda S, DiDonato JA, Brown JM, Gogonea V, Lusis AJ, Garcia-Garcia JC, Hazen SL. Roberts AB, et al. Among authors: skye sm. Nat Med. 2018 Sep;24(9):1407-1417. doi: 10.1038/s41591-018-0128-1. Epub 2018 Aug 6. Nat Med. 2018. PMID: 30082863 Free PMC article.
Dietary Choline Supplements, but Not Eggs, Raise Fasting TMAO Levels in Participants with Normal Renal Function: A Randomized Clinical Trial.
Wilcox J, Skye SM, Graham B, Zabell A, Li XS, Li L, Shelkay S, Fu X, Neale S, O'Laughlin C, Peterson K, Hazen SL, Tang WHW. Wilcox J, et al. Among authors: skye sm. Am J Med. 2021 Sep;134(9):1160-1169.e3. doi: 10.1016/j.amjmed.2021.03.016. Epub 2021 Apr 17. Am J Med. 2021. PMID: 33872583 Free PMC article. Clinical Trial.
Microbe-derived uremic solutes enhance thrombosis potential in the host.
Nemet I, Funabashi M, Li XS, Dwidar M, Sangwan N, Skye SM, Romano KA, Cajka T, Needham BD, Mazmanian SK, Hajjar AM, Rey FE, Fiehn O, Tang WHW, Fischbach MA, Hazen SL. Nemet I, et al. Among authors: skye sm. mBio. 2023 Dec 19;14(6):e0133123. doi: 10.1128/mbio.01331-23. Epub 2023 Nov 10. mBio. 2023. PMID: 37947418 Free PMC article.