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Utilizing minimally purified secreted rAAV for rapid and cost-effective manipulation of gene expression in the CNS.
Goodwin MS, Croft CL, Futch HS, Ryu D, Ceballos-Diaz C, Liu X, Paterno G, Mejia C, Deng D, Menezes K, Londono L, Arjona K, Parianos M, Truong V, Rostonics E, Hernandez A, Boye SL, Boye SE, Levites Y, Cruz PE, Golde TE. Goodwin MS, et al. Among authors: cruz pe. Mol Neurodegener. 2020 Mar 2;15(1):15. doi: 10.1186/s13024-020-00361-z. Mol Neurodegener. 2020. PMID: 32122372 Free PMC article.
Modulating innate immune activation states impacts the efficacy of specific Aβ immunotherapy.
Levites Y, Funk C, Wang X, Chakrabarty P, McFarland KN, Bramblett B, O'Neal V, Liu X, Ladd T, Robinson M, Allen M, Carrasquillo MM, Dickson D, Cruz P, Ryu D, Li HD, Price ND, Ertekin-Taner N, Golde TE. Levites Y, et al. Mol Neurodegener. 2021 May 6;16(1):32. doi: 10.1186/s13024-021-00453-4. Mol Neurodegener. 2021. PMID: 33957936 Free PMC article.
Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice.
Ayers JI, Fromholt S, Sinyavskaya O, Siemienski Z, Rosario AM, Li A, Crosby KW, Cruz PE, DiNunno NM, Janus C, Ceballos-Diaz C, Borchelt DR, Golde TE, Chakrabarty P, Levites Y. Ayers JI, et al. Among authors: cruz pe. Mol Ther. 2015 Jan;23(1):53-62. doi: 10.1038/mt.2014.180. Epub 2014 Sep 17. Mol Ther. 2015. PMID: 25228069 Free PMC article.
IFN-γ promotes τ phosphorylation without affecting mature tangles.
Li A, Ceballos-Diaz C, DiNunno N, Levites Y, Cruz PE, Lewis J, Golde TE, Chakrabarty P. Li A, et al. Among authors: cruz pe. FASEB J. 2015 Oct;29(10):4384-98. doi: 10.1096/fj.15-275834. Epub 2015 Jul 8. FASEB J. 2015. PMID: 26156074 Free PMC article.
Photodynamic studies reveal rapid formation and appreciable turnover of tau inclusions.
Croft CL, Goodwin MS, Ryu DH, Lessard CB, Tejeda G, Marrero M, Vause AR, Paterno G, Cruz PE, Lewis J, Giasson BI, Golde TE. Croft CL, et al. Among authors: cruz pe. Acta Neuropathol. 2021 Mar;141(3):359-381. doi: 10.1007/s00401-021-02264-9. Epub 2021 Jan 26. Acta Neuropathol. 2021. PMID: 33496840 Free PMC article.
139 results