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Nine-Step Stereoselective Synthesis of Islatravir from Deoxyribose.
Nawrat CC, Whittaker AM, Huffman MA, McLaughlin M, Cohen RD, Andreani T, Ding B, Li H, Weisel M, Tschaen DM. Nawrat CC, et al. Among authors: andreani t. Org Lett. 2020 Mar 20;22(6):2167-2172. doi: 10.1021/acs.orglett.0c00239. Epub 2020 Feb 28. Org Lett. 2020. PMID: 32108487
Discovery of hydroxy pyrimidine Factor IXa inhibitors.
Jayne CL, Andreani T, Chan TY, Chelliah MV, Clasby MC, Dwyer M, Eagen KA, Fried S, Greenlee WJ, Guo Z, Hawes B, Hruza A, Ingram R, Keertikar KM, Neelamkavil S, Reichert P, Xia Y, Chackalamannil S. Jayne CL, et al. Among authors: andreani t. Bioorg Med Chem Lett. 2020 Aug 1;30(15):127279. doi: 10.1016/j.bmcl.2020.127279. Epub 2020 May 23. Bioorg Med Chem Lett. 2020. PMID: 32527459
The discovery of N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): a potent and selective glucagon receptor antagonist.
DeMong D, Dai X, Hwa J, Miller M, Lin SI, Kang L, Stamford A, Greenlee W, Yu W, Wong M, Lavey B, Kozlowski J, Zhou G, Yang DY, Patel B, Soriano A, Zhai Y, Sondey C, Zhang H, Lachowicz J, Grotz D, Cox K, Morrison R, Andreani T, Cao Y, Liang M, Meng T, McNamara P, Wong J, Bradley P, Feng KI, Belani J, Chen P, Dai P, Gauuan J, Lin P, Zhao H. DeMong D, et al. Among authors: andreani t. J Med Chem. 2014 Mar 27;57(6):2601-10. doi: 10.1021/jm401858f. Epub 2014 Feb 26. J Med Chem. 2014. PMID: 24527772
Attribute ranging as a coordinated strategy between drug substance and drug product to accelerate commercial process nomination.
Hartmanshenn C, Bechtold A, Kwok T, Mora J, Contrella N, Confer A, Bade R, Andreani T, Hughes JME, Chen B, Sirota E, Codan L, Lamberto DJ, Xu Y, Salehi N, Crowley S. Hartmanshenn C, et al. Among authors: andreani t. J Pharm Sci. 2024 Dec 5:S0022-3549(24)00513-6. doi: 10.1016/j.xphs.2024.11.008. Online ahead of print. J Pharm Sci. 2024. PMID: 39645078
114 results