Ruan Z - Search Results

1

Emerging roles of the αC-β4 loop in protein kinase structure, function, evolution, and disease.

Yeung W, Ruan Z, Kannan N. Yeung W, et al. Among authors: ruan z. IUBMB Life. 2020 Jun;72(6):1189-1202. doi: 10.1002/iub.2253. Epub 2020 Feb 26. IUBMB Life. 2020. PMID: 32101380 Free PMC article. Review.

2

Co-conserved MAPK features couple D-domain docking groove to distal allosteric sites via the C-terminal flanking tail.

Nguyen T, Ruan Z, Oruganty K, Kannan N. Nguyen T, et al. Among authors: ruan z. PLoS One. 2015 Mar 23;10(3):e0119636. doi: 10.1371/journal.pone.0119636. eCollection 2015. PLoS One. 2015. PMID: 25799139 Free PMC article.

3

Mechanistic Insights into R776H Mediated Activation of Epidermal Growth Factor Receptor Kinase.

Ruan Z, Kannan N. Ruan Z, et al. Biochemistry. 2015 Jul 14;54(27):4216-25. doi: 10.1021/acs.biochem.5b00444. Epub 2015 Jul 6. Biochemistry. 2015. PMID: 26101090 Free PMC article.

4

Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.

Mohanty S, Oruganty K, Kwon A, Byrne DP, Ferries S, Ruan Z, Hanold LE, Katiyar S, Kennedy EJ, Eyers PA, Kannan N. Mohanty S, et al. Among authors: ruan z. PLoS Genet. 2016 Feb 29;12(2):e1005885. doi: 10.1371/journal.pgen.1005885. eCollection 2016 Feb. PLoS Genet. 2016. PMID: 26925779 Free PMC article.

5

Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity.

Stefely JA, Licitra F, Laredj L, Reidenbach AG, Kemmerer ZA, Grangeray A, Jaeg-Ehret T, Minogue CE, Ulbrich A, Hutchins PD, Wilkerson EM, Ruan Z, Aydin D, Hebert AS, Guo X, Freiberger EC, Reutenauer L, Jochem A, Chergova M, Johnson IE, Lohman DC, Rush MJP, Kwiecien NW, Singh PK, Schlagowski AI, Floyd BJ, Forsman U, Sindelar PJ, Westphall MS, Pierrel F, Zoll J, Dal Peraro M, Kannan N, Bingman CA, Coon JJ, Isope P, Puccio H, Pagliarini DJ. Stefely JA, et al. Among authors: ruan z. Mol Cell. 2016 Aug 18;63(4):608-620. doi: 10.1016/j.molcel.2016.06.030. Epub 2016 Aug 4. Mol Cell. 2016. PMID: 27499294 Free PMC article.

6

Correction: Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.

Mohanty S, Oruganty K, Kwon A, Byrne DP, Ferries S, Ruan Z, Hanold LE, Katiyar S, Kennedy EJ, Eyers PA, Kannan N. Mohanty S, et al. Among authors: ruan z. PLoS Genet. 2016 Aug 11;12(8):e1006265. doi: 10.1371/journal.pgen.1006265. eCollection 2016 Aug. PLoS Genet. 2016. PMID: 27513745 Free PMC article.

7

Computational and Experimental Characterization of Patient Derived Mutations Reveal an Unusual Mode of Regulatory Spine Assembly and Drug Sensitivity in EGFR Kinase.

Ruan Z, Katiyar S, Kannan N. Ruan Z, et al. Biochemistry. 2017 Jan 10;56(1):22-32. doi: 10.1021/acs.biochem.6b00572. Epub 2016 Dec 22. Biochemistry. 2017. PMID: 27936599 Free PMC article.

8

The Hippo Pathway Maintains the Equatorial Division Plane in the Ciliate Tetrahymena.

Jiang YY, Maier W, Baumeister R, Minevich G, Joachimiak E, Ruan Z, Kannan N, Clarke D, Frankel J, Gaertig J. Jiang YY, et al. Among authors: ruan z. Genetics. 2017 Jun;206(2):873-888. doi: 10.1534/genetics.117.200766. Epub 2017 Apr 16. Genetics. 2017. PMID: 28413159 Free PMC article.

9

Conformationally constrained peptides target the allosteric kinase dimer interface and inhibit EGFR activation.

Fulton MD, Hanold LE, Ruan Z, Patel S, Beedle AM, Kannan N, Kennedy EJ. Fulton MD, et al. Among authors: ruan z. Bioorg Med Chem. 2018 Mar 15;26(6):1167-1173. doi: 10.1016/j.bmc.2017.08.051. Epub 2017 Sep 5. Bioorg Med Chem. 2018. PMID: 28911855 Free PMC article.

10

Coupled regulation by the juxtamembrane and sterile α motif (SAM) linker is a hallmark of ephrin tyrosine kinase evolution.

Kwon A, John M, Ruan Z, Kannan N. Kwon A, et al. Among authors: ruan z. J Biol Chem. 2018 Apr 6;293(14):5102-5116. doi: 10.1074/jbc.RA117.001296. Epub 2018 Feb 12. J Biol Chem. 2018. PMID: 29432127 Free PMC article.

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