Kannan N - Search Results

1

Emerging roles of the αC-β4 loop in protein kinase structure, function, evolution, and disease.

Yeung W, Ruan Z, Kannan N. Yeung W, et al. Among authors: kannan n. IUBMB Life. 2020 Jun;72(6):1189-1202. doi: 10.1002/iub.2253. Epub 2020 Feb 26. IUBMB Life. 2020. PMID: 32101380 Free PMC article. Review.

2

Conformational regulation of the EGFR kinase core by the juxtamembrane and C-terminal tail: a molecular dynamics study.

Mustafa M, Mirza A, Kannan N. Mustafa M, et al. Among authors: kannan n. Proteins. 2011 Jan;79(1):99-114. doi: 10.1002/prot.22862. Epub 2010 Oct 11. Proteins. 2011. PMID: 20938978

3

Structural and evolutionary divergence of eukaryotic protein kinases in Apicomplexa.

Talevich E, Mirza A, Kannan N. Talevich E, et al. Among authors: kannan n. BMC Evol Biol. 2011 Nov 2;11:321. doi: 10.1186/1471-2148-11-321. BMC Evol Biol. 2011. PMID: 22047078 Free PMC article.

4

Identification of a hidden strain switch provides clues to an ancient structural mechanism in protein kinases.

Oruganty K, Talathi NS, Wood ZA, Kannan N. Oruganty K, et al. Among authors: kannan n. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):924-9. doi: 10.1073/pnas.1207104110. Epub 2012 Dec 31. Proc Natl Acad Sci U S A. 2013. PMID: 23277537 Free PMC article.

5

Evolutionary variation and adaptation in a conserved protein kinase allosteric network: implications for inhibitor design.

Oruganty K, Kannan N. Oruganty K, et al. Among authors: kannan n. Biochim Biophys Acta. 2013 Jul;1834(7):1322-9. doi: 10.1016/j.bbapap.2013.02.040. Epub 2013 Mar 14. Biochim Biophys Acta. 2013. PMID: 23499783

6

Structural and evolutionary adaptation of rhoptry kinases and pseudokinases, a family of coccidian virulence factors.

Talevich E, Kannan N. Talevich E, et al. Among authors: kannan n. BMC Evol Biol. 2013 Jun 6;13:117. doi: 10.1186/1471-2148-13-117. BMC Evol Biol. 2013. PMID: 23742205 Free PMC article.

7

Co-conserved MAPK features couple D-domain docking groove to distal allosteric sites via the C-terminal flanking tail.

Nguyen T, Ruan Z, Oruganty K, Kannan N. Nguyen T, et al. Among authors: kannan n. PLoS One. 2015 Mar 23;10(3):e0119636. doi: 10.1371/journal.pone.0119636. eCollection 2015. PLoS One. 2015. PMID: 25799139 Free PMC article.

8

Integration of signaling in the kinome: Architecture and regulation of the αC Helix.

Taylor SS, Shaw AS, Kannan N, Kornev AP. Taylor SS, et al. Among authors: kannan n. Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1567-74. doi: 10.1016/j.bbapap.2015.04.007. Epub 2015 Apr 17. Biochim Biophys Acta. 2015. PMID: 25891902 Free PMC article.

9

Mechanistic Insights into R776H Mediated Activation of Epidermal Growth Factor Receptor Kinase.

Ruan Z, Kannan N. Ruan Z, et al. Among authors: kannan n. Biochemistry. 2015 Jul 14;54(27):4216-25. doi: 10.1021/acs.biochem.5b00444. Epub 2015 Jul 6. Biochemistry. 2015. PMID: 26101090 Free PMC article.

10

Identification and classification of small molecule kinases: insights into substrate recognition and specificity.

Oruganty K, Talevich EE, Neuwald AF, Kannan N. Oruganty K, et al. Among authors: kannan n. BMC Evol Biol. 2016 Jan 6;16:7. doi: 10.1186/s12862-015-0576-x. BMC Evol Biol. 2016. PMID: 26738562 Free PMC article.

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