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Prostaglandin E2 in a TLR3- and 7/8-agonist-based DC maturation cocktail generates mature, cytokine-producing, migratory DCs but impairs antigen cross-presentation to CD8+ T cells.
Gierlich P, Lex V, Technau A, Keupp A, Morper L, Glunz A, Sennholz H, Rachor J, Sauer S, Marcu A, Grigoleit GU, Wölfl M, Schlegel PG, Eyrich M. Gierlich P, et al. Among authors: technau a. Cancer Immunol Immunother. 2020 Jun;69(6):1029-1042. doi: 10.1007/s00262-019-02470-1. Epub 2020 Feb 25. Cancer Immunol Immunother. 2020. PMID: 32100075 Free PMC article.
High-grade glioma associated immunosuppression does not prevent immune responses induced by therapeutic vaccines in combination with Treg depletion.
Löhr M, Freitag B, Technau A, Krauss J, Monoranu CM, Rachor J, Lutz MB, Hagemann C, Kessler AF, Linsenmann T, Wölfl M, Ernestus RI, Engelhardt S, Gelbrich G, Schlegel PG, Eyrich M. Löhr M, et al. Among authors: technau a. Cancer Immunol Immunother. 2018 Oct;67(10):1545-1558. doi: 10.1007/s00262-018-2214-0. Epub 2018 Jul 27. Cancer Immunol Immunother. 2018. PMID: 30054667 Free PMC article.
25 results