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Prostaglandin E2 in a TLR3- and 7/8-agonist-based DC maturation cocktail generates mature, cytokine-producing, migratory DCs but impairs antigen cross-presentation to CD8+ T cells.
Gierlich P, Lex V, Technau A, Keupp A, Morper L, Glunz A, Sennholz H, Rachor J, Sauer S, Marcu A, Grigoleit GU, Wölfl M, Schlegel PG, Eyrich M. Gierlich P, et al. Among authors: rachor j. Cancer Immunol Immunother. 2020 Jun;69(6):1029-1042. doi: 10.1007/s00262-019-02470-1. Epub 2020 Feb 25. Cancer Immunol Immunother. 2020. PMID: 32100075 Free PMC article.
High-grade glioma associated immunosuppression does not prevent immune responses induced by therapeutic vaccines in combination with Treg depletion.
Löhr M, Freitag B, Technau A, Krauss J, Monoranu CM, Rachor J, Lutz MB, Hagemann C, Kessler AF, Linsenmann T, Wölfl M, Ernestus RI, Engelhardt S, Gelbrich G, Schlegel PG, Eyrich M. Löhr M, et al. Among authors: rachor j. Cancer Immunol Immunother. 2018 Oct;67(10):1545-1558. doi: 10.1007/s00262-018-2214-0. Epub 2018 Jul 27. Cancer Immunol Immunother. 2018. PMID: 30054667 Free PMC article.
Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma.
Schuster SJ, Bishop MR, Tam CS, Waller EK, Borchmann P, McGuirk JP, Jäger U, Jaglowski S, Andreadis C, Westin JR, Fleury I, Bachanova V, Foley SR, Ho PJ, Mielke S, Magenau JM, Holte H, Pantano S, Pacaud LB, Awasthi R, Chu J, Anak Ö, Salles G, Maziarz RT; JULIET Investigators. Schuster SJ, et al. N Engl J Med. 2019 Jan 3;380(1):45-56. doi: 10.1056/NEJMoa1804980. Epub 2018 Dec 1. N Engl J Med. 2019. PMID: 30501490 Clinical Trial.
Improvement of Bone Healing by Neutralization of microRNA-335-5p, but not by Neutralization of microRNA-92A in Bone Marrow Mononuclear Cells Transplanted into a Large Femur Defect of the Rat.
Janko M, Dietz K, Rachor J, Sahm J, Schroder K, Schaible A, Nau C, Seebach C, Marzi I, Henrich D. Janko M, et al. Among authors: rachor j. Tissue Eng Part A. 2019 Jan;25(1-2):55-68. doi: 10.1089/ten.TEA.2017.0479. Epub 2018 Apr 23. Tissue Eng Part A. 2019. PMID: 29652605