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Effects of rigidity on the selectivity of protein kinase inhibitors.
Assadieskandar A, Yu C, Maisonneuve P, Liu X, Chen YC, Prakash GKS, Kurinov I, Sicheri F, Zhang C. Assadieskandar A, et al. Among authors: maisonneuve p. Eur J Med Chem. 2018 Feb 25;146:519-528. doi: 10.1016/j.ejmech.2018.01.053. Epub 2018 Jan 31. Eur J Med Chem. 2018. PMID: 29407977 Free PMC article.
MEK drives BRAF activation through allosteric control of KSR proteins.
Lavoie H, Sahmi M, Maisonneuve P, Marullo SA, Thevakumaran N, Jin T, Kurinov I, Sicheri F, Therrien M. Lavoie H, et al. Among authors: maisonneuve p. Nature. 2018 Feb 22;554(7693):549-553. doi: 10.1038/nature25478. Epub 2018 Feb 12. Nature. 2018. PMID: 29433126 Free PMC article.
Rigidification Dramatically Improves Inhibitor Selectivity for RAF Kinases.
Assadieskandar A, Yu C, Maisonneuve P, Kurinov I, Sicheri F, Zhang C. Assadieskandar A, et al. Among authors: maisonneuve p. ACS Med Chem Lett. 2019 Jun 4;10(7):1074-1080. doi: 10.1021/acsmedchemlett.9b00194. eCollection 2019 Jul 11. ACS Med Chem Lett. 2019. PMID: 31312411 Free PMC article.
Functional characterization of a PROTAC directed against BRAF mutant V600E.
Posternak G, Tang X, Maisonneuve P, Jin T, Lavoie H, Daou S, Orlicky S, Goullet de Rugy T, Caldwell L, Chan K, Aman A, Prakesch M, Poda G, Mader P, Wong C, Maier S, Kitaygorodsky J, Larsen B, Colwill K, Yin Z, Ceccarelli DF, Batey RA, Taipale M, Kurinov I, Uehling D, Wrana J, Durocher D, Gingras AC, Al-Awar R, Therrien M, Sicheri F. Posternak G, et al. Among authors: maisonneuve p. Nat Chem Biol. 2020 Nov;16(11):1170-1178. doi: 10.1038/s41589-020-0609-7. Epub 2020 Aug 10. Nat Chem Biol. 2020. PMID: 32778845 Free PMC article.
A substrate binding model for the KEOPS tRNA modifying complex.
Beenstock J, Ona SM, Porat J, Orlicky S, Wan LCK, Ceccarelli DF, Maisonneuve P, Szilard RK, Yin Z, Setiaputra D, Mao DYL, Khan M, Raval S, Schriemer DC, Bayfield MA, Durocher D, Sicheri F. Beenstock J, et al. Among authors: maisonneuve p. Nat Commun. 2020 Dec 4;11(1):6233. doi: 10.1038/s41467-020-19990-5. Nat Commun. 2020. PMID: 33277478 Free PMC article.
Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.
Chana CK, Maisonneuve P, Posternak G, Grinberg NGA, Poirson J, Ona SM, Ceccarelli DF, Mader P, St-Cyr DJ, Pau V, Kurinov I, Tang X, Deng D, Cui W, Su W, Kuai L, Soll R, Tyers M, Röst HL, Batey RA, Taipale M, Gingras AC, Sicheri F. Chana CK, et al. Among authors: maisonneuve p. J Med Chem. 2022 Oct 13;65(19):12725-12746. doi: 10.1021/acs.jmedchem.2c00509. Epub 2022 Sep 18. J Med Chem. 2022. PMID: 36117290 Free PMC article.
High Accuracy Prediction of PROTAC Complex Structures.
Ignatov M, Jindal A, Kotelnikov S, Beglov D, Posternak G, Tang X, Maisonneuve P, Poda G, Batey RA, Sicheri F, Whitty A, Tonge PJ, Vajda S, Kozakov D. Ignatov M, et al. Among authors: maisonneuve p. J Am Chem Soc. 2023 Apr 5;145(13):7123-7135. doi: 10.1021/jacs.2c09387. Epub 2023 Mar 24. J Am Chem Soc. 2023. PMID: 36961978 Free PMC article.
668 results