Ernst A - Search Results

1

Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids.

Wiechmann S, Maisonneuve P, Grebbin BM, Hoffmeister M, Kaulich M, Clevers H, Rajalingam K, Kurinov I, Farin HF, Sicheri F, Ernst A. Wiechmann S, et al. Among authors: ernst a. J Biol Chem. 2020 Apr 3;295(14):4526-4540. doi: 10.1074/jbc.RA119.011025. Epub 2020 Feb 20. J Biol Chem. 2020. PMID: 32086379 Free PMC article.

2

Site-specific inhibition of the small ubiquitin-like modifier (SUMO)-conjugating enzyme Ubc9 selectively impairs SUMO chain formation.

Wiechmann S, Gärtner A, Kniss A, Stengl A, Behrends C, Rogov VV, Rodriguez MS, Dötsch V, Müller S, Ernst A. Wiechmann S, et al. Among authors: ernst a. J Biol Chem. 2017 Sep 15;292(37):15340-15351. doi: 10.1074/jbc.M117.794255. Epub 2017 Aug 7. J Biol Chem. 2017. PMID: 28784659 Free PMC article.

3

Comprehensive analysis of all evolutionary paths between two divergent PDZ domain specificities.

Teyra J, Ernst A, Singer A, Sicheri F, Sidhu SS. Teyra J, et al. Among authors: ernst a. Protein Sci. 2020 Feb;29(2):433-442. doi: 10.1002/pro.3759. Epub 2019 Nov 14. Protein Sci. 2020. PMID: 31654425 Free PMC article.

4

Dimerization of a ubiquitin variant leads to high affinity interactions with a ubiquitin interacting motif.

Manczyk N, Veggiani G, Gish GD, Yates BP, Ernst A, Sidhu SS, Sicheri F. Manczyk N, et al. Among authors: ernst a. Protein Sci. 2019 May;28(5):848-856. doi: 10.1002/pro.3593. Epub 2019 Mar 12. Protein Sci. 2019. PMID: 30793400 Free PMC article.

5

Structural and functional characterization of a ubiquitin variant engineered for tight and specific binding to an alpha-helical ubiquitin interacting motif.

Manczyk N, Yates BP, Veggiani G, Ernst A, Sicheri F, Sidhu SS. Manczyk N, et al. Among authors: ernst a. Protein Sci. 2017 May;26(5):1060-1069. doi: 10.1002/pro.3155. Epub 2017 Mar 24. Protein Sci. 2017. PMID: 28276594 Free PMC article.

6

Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome.

Wegner M, Diehl V, Bittl V, de Bruyn R, Wiechmann S, Matthess Y, Hebel M, Hayes MG, Schaubeck S, Benner C, Heinz S, Bremm A, Dikic I, Ernst A, Kaulich M. Wegner M, et al. Among authors: ernst a. Elife. 2019 Mar 6;8:e42549. doi: 10.7554/eLife.42549. Elife. 2019. PMID: 30838976 Free PMC article.

7

Comprehensive Assessment of the Relationship Between Site^-2 Specificity and Helix α2 in the Erbin PDZ Domain.

Teyra J, McLaughlin M, Singer A, Kelil A, Ernst A, Sicheri F, Sidhu SS. Teyra J, et al. Among authors: ernst a. J Mol Biol. 2021 Sep 3;433(18):167115. doi: 10.1016/j.jmb.2021.167115. Epub 2021 Jun 24. J Mol Biol. 2021. PMID: 34171344

8

IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells.

Han Y, Mora J, Huard A, da Silva P, Wiechmann S, Putyrski M, Schuster C, Elwakeel E, Lang G, Scholz A, Scholz T, Schmid T, de Bruin N, Billuart P, Sala C, Burkhardt H, Parnham MJ, Ernst A, Brüne B, Weigert A. Han Y, et al. Among authors: ernst a. Cell Rep. 2019 Apr 16;27(3):835-846.e5. doi: 10.1016/j.celrep.2019.03.082. Cell Rep. 2019. PMID: 30995480 Free article.

9

Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency.

Canny MD, Moatti N, Wan LCK, Fradet-Turcotte A, Krasner D, Mateos-Gomez PA, Zimmermann M, Orthwein A, Juang YC, Zhang W, Noordermeer SM, Seclen E, Wilson MD, Vorobyov A, Munro M, Ernst A, Ng TF, Cho T, Cannon PM, Sidhu SS, Sicheri F, Durocher D. Canny MD, et al. Among authors: ernst a. Nat Biotechnol. 2018 Jan;36(1):95-102. doi: 10.1038/nbt.4021. Epub 2017 Nov 27. Nat Biotechnol. 2018. PMID: 29176614 Free PMC article.

10

A strategy for modulation of enzymes in the ubiquitin system.

Ernst A, Avvakumov G, Tong J, Fan Y, Zhao Y, Alberts P, Persaud A, Walker JR, Neculai AM, Neculai D, Vorobyov A, Garg P, Beatty L, Chan PK, Juang YC, Landry MC, Yeh C, Zeqiraj E, Karamboulas K, Allali-Hassani A, Vedadi M, Tyers M, Moffat J, Sicheri F, Pelletier L, Durocher D, Raught B, Rotin D, Yang J, Moran MF, Dhe-Paganon S, Sidhu SS. Ernst A, et al. Science. 2013 Feb 1;339(6119):590-5. doi: 10.1126/science.1230161. Epub 2013 Jan 3. Science. 2013. PMID: 23287719 Free PMC article.

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