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7-Deaza-7-fluoro modification confers on 4'-cyano-nucleosides potent activity against entecavir/adefovir-resistant HBV variants and favorable safety.
Hayashi S, Higashi-Kuwata N, Das D, Tomaya K, Yamada K, Murakami S, Venzon DJ, Hattori SI, Isogawa M, Sarafianos SG, Mitsuya H, Tanaka Y. Hayashi S, et al. Among authors: tomaya k. Antiviral Res. 2020 Apr;176:104744. doi: 10.1016/j.antiviral.2020.104744. Epub 2020 Feb 18. Antiviral Res. 2020. PMID: 32084506 Free PMC article.