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Inhibitors of dihydrofolate reductase as antitumor agents: design, synthesis and biological evaluation of a series of novel nonclassical 6-substituted pyrido[3,2-d]pyrimidines with a three- to five-carbon bridge.
Li H, Fang F, Liu Y, Xue L, Wang M, Guo Y, Wang X, Tian C, Liu J, Zhang Z. Li H, et al. Among authors: fang f. Bioorg Med Chem. 2018 May 15;26(9):2674-2685. doi: 10.1016/j.bmc.2018.04.035. Epub 2018 Apr 19. Bioorg Med Chem. 2018. PMID: 29691154
Design, synthesis and biological activity of N5-substituted tetrahydropteroate analogs as non-classical antifolates against cobalamin-dependent methionine synthase and potential anticancer agents.
Wang M, Tian C, Xue L, Li H, Cong J, Fang F, Yang J, Yuan M, Chen Y, Guo Y, Wang X, Liu J, Zhang Z. Wang M, et al. Among authors: fang f. Eur J Med Chem. 2020 Mar 15;190:112113. doi: 10.1016/j.ejmech.2020.112113. Epub 2020 Feb 5. Eur J Med Chem. 2020. PMID: 32058237
4,867 results