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Dipyrone is locally hydrolyzed to 4-methylaminoantipyrine and its antihyperalgesic effect depends on CB2 and kappa-opioid receptors activation.
Gonçalves Dos Santos G, Vieira WF, Vendramini PH, Bassani da Silva B, Fernandes Magalhães S, Tambeli CH, Parada CA. Gonçalves Dos Santos G, et al. Among authors: fernandes magalhaes s. Eur J Pharmacol. 2020 May 5;874:173005. doi: 10.1016/j.ejphar.2020.173005. Epub 2020 Feb 11. Eur J Pharmacol. 2020. PMID: 32057719 Free article.