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A redox-active switch in fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily.
Shrestha S, Katiyar S, Sanz-Rodriguez CE, Kemppinen NR, Kim HW, Kadirvelraj R, Panagos C, Keyhaninejad N, Colonna M, Chopra P, Byrne DP, Boons GJ, van der Knaap E, Eyers PA, Edison AS, Wood ZA, Kannan N. Shrestha S, et al. Sci Signal. 2020 Jul 7;13(639):eaax6313. doi: 10.1126/scisignal.aax6313. Sci Signal. 2020. PMID: 32636308 Free PMC article.
A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.
Picado A, Chaikuad A, Wells CI, Shrestha S, Zuercher WJ, Pickett JE, Kwarcinski FE, Sinha P, de Silva CS, Zutshi R, Liu S, Kannan N, Knapp S, Drewry DH, Willson TM. Picado A, et al. Among authors: shrestha s. J Med Chem. 2020 Dec 10;63(23):14626-14646. doi: 10.1021/acs.jmedchem.0c01174. Epub 2020 Nov 20. J Med Chem. 2020. PMID: 33215924 Free PMC article.
Computational tools and resources for pseudokinase research.
O'Boyle B, Shrestha S, Kochut K, Eyers PA, Kannan N. O'Boyle B, et al. Among authors: shrestha s. Methods Enzymol. 2022;667:403-426. doi: 10.1016/bs.mie.2022.03.040. Epub 2022 Apr 8. Methods Enzymol. 2022. PMID: 35525549 Free PMC article. Review.
Evolutionary and cellular analysis of the 'dark' pseudokinase PSKH2.
Byrne DP, Shrestha S, Daly LA, Marensi V, Ramakrishnan K, Eyers CE, Kannan N, Eyers PA. Byrne DP, et al. Among authors: shrestha s. Biochem J. 2023 Jan 31;480(2):141-160. doi: 10.1042/BCJ20220474. Biochem J. 2023. PMID: 36520605 Free PMC article.
3,380 results