Cochrane CS - Search Results

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Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics.

Cho J, Lee M, Cochrane CS, Webster CG, Fenton BA, Zhao J, Hong J, Zhou P. Cho J, et al. Among authors: cochrane cs. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4109-4116. doi: 10.1073/pnas.1912876117. Epub 2020 Feb 10. Proc Natl Acad Sci U S A. 2020. PMID: 32041866 Free PMC article.

Synthesis and evaluation of sulfonyl piperazine LpxH inhibitors.

Kwak SH, Cochrane CS, Ennis AF, Lim WY, Webster CG, Cho J, Fenton BA, Zhou P, Hong J. Kwak SH, et al. Among authors: cochrane cs. Bioorg Chem. 2020 Sep;102:104055. doi: 10.1016/j.bioorg.2020.104055. Epub 2020 Jun 30. Bioorg Chem. 2020. PMID: 32663666 Free PMC article.

Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens.

Zhao J, Cochrane CS, Najeeb J, Gooden D, Sciandra C, Fan P, Lemaitre N, Newns K, Nicholas RA, Guan Z, Thaden JT, Fowler VG Jr, Spasojevic I, Sebbane F, Toone EJ, Duncan C, Gammans R, Zhou P. Zhao J, et al. Among authors: cochrane cs. Sci Transl Med. 2023 Aug 9;15(708):eadf5668. doi: 10.1126/scitranslmed.adf5668. Epub 2023 Aug 9. Sci Transl Med. 2023. PMID: 37556556 Free PMC article.

Design and Evaluation of Pyridinyl Sulfonyl Piperazine LpxH Inhibitors with Potent Antibiotic Activity Against Enterobacterales.

Ennis AF, Cochrane CS, Dome PA, Jeong P, Yu J, Lee H, Williams CS, Ha Y, Yang W, Zhou P, Hong J. Ennis AF, et al. Among authors: cochrane cs. JACS Au. 2024 Nov 11;4(11):4383-4393. doi: 10.1021/jacsau.4c00731. eCollection 2024 Nov 25. JACS Au. 2024. PMID: 39610720 Free PMC article.

L-DOPA Dioxygenase Activity on 6-Substituted Dopamine Analogues.

Goldberg AM, Robinson MK, Starr ES, Marasco RN, Alana AC, Cochrane CS, Klugh KL, Strzeminski DJ, Du M, Colabroy KL, Peterson LW. Goldberg AM, et al. Among authors: cochrane cs. Biochemistry. 2021 Aug 17;60(32):2492-2507. doi: 10.1021/acs.biochem.1c00310. Epub 2021 Jul 29. Biochemistry. 2021. PMID: 34324302

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