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Page 1
Single-cell genomics details the maturation block in BCP-ALL and identifies therapeutic vulnerabilities in DUX4-r cases.
Thorsson H, Henningsson R, Puente-Moncada N, Peña-Martínez P, Sjöström L, Ågerstam H, Sandén C, Rissler M, Castor A, Marquart H, Modvig S, Paulsson K, Pronk CJ, Schmiegelow K, Hyrenius-Wittsten A, Orsmark-Pietras C, Lilljebjörn H, Fioretos T. Thorsson H, et al. Blood. 2024 Sep 26;144(13):1399-1411. doi: 10.1182/blood.2023021705. Blood. 2024. PMID: 38968149 Free PMC article.
The complement receptor C3AR constitutes a novel therapeutic target in NPM1-mutated AML.
von Palffy S, Thorsson H, Peña-Martínez P, Puente-Moncada N, Sandén C, Blom AM, Henningsson R, Juliusson G, King B, Landberg N, Lazarevic V, Orsmark-Pietras C, Rissler M, Rissler V, Ågerstam H, Järås M, Lilljebjörn H, Fioretos T. von Palffy S, et al. Among authors: thorsson h. Blood Adv. 2023 Apr 11;7(7):1204-1218. doi: 10.1182/bloodadvances.2022007682. Blood Adv. 2023. PMID: 36383712 Free PMC article.
Clonal competition within complex evolutionary hierarchies shapes AML over time.
Sandén C, Lilljebjörn H, Orsmark Pietras C, Henningsson R, Saba KH, Landberg N, Thorsson H, von Palffy S, Peña-Martinez P, Högberg C, Rissler M, Gisselsson D, Lazarevic V, Juliusson G, Ågerstam H, Fioretos T. Sandén C, et al. Among authors: thorsson h. Nat Commun. 2020 Feb 5;11(1):579. doi: 10.1038/s41467-019-14106-0. Nat Commun. 2020. PMID: 32024830 Free PMC article.