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Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.
Brydges SD, Mueller JL, McGeough MD, Pena CA, Misaghi A, Gandhi C, Putnam CD, Boyle DL, Firestein GS, Horner AA, Soroosh P, Watford WT, O'Shea JJ, Kastner DL, Hoffman HM. Brydges SD, et al. Among authors: mcgeough md. Immunity. 2009 Jun 19;30(6):875-87. doi: 10.1016/j.immuni.2009.05.005. Epub 2009 Jun 4. Immunity. 2009. PMID: 19501000 Free PMC article.
Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice.
Bonar SL, Brydges SD, Mueller JL, McGeough MD, Pena C, Chen D, Grimston SK, Hickman-Brecks CL, Ravindran S, McAlinden A, Novack DV, Kastner DL, Civitelli R, Hoffman HM, Mbalaviele G. Bonar SL, et al. Among authors: mcgeough md. PLoS One. 2012;7(4):e35979. doi: 10.1371/journal.pone.0035979. Epub 2012 Apr 27. PLoS One. 2012. PMID: 22558291 Free PMC article.
NLRP3 inflammasome activation is required for fibrosis development in NAFLD.
Wree A, McGeough MD, Peña CA, Schlattjan M, Li H, Inzaugarat ME, Messer K, Canbay A, Hoffman HM, Feldstein AE. Wree A, et al. Among authors: mcgeough md. J Mol Med (Berl). 2014 Oct;92(10):1069-82. doi: 10.1007/s00109-014-1170-1. Epub 2014 May 28. J Mol Med (Berl). 2014. PMID: 24861026 Free PMC article.
NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms.
Qu C, Bonar SL, Hickman-Brecks CL, Abu-Amer S, McGeough MD, Peña CA, Broderick L, Yang C, Grimston SK, Kading J, Abu-Amer Y, Novack DV, Hoffman HM, Civitelli R, Mbalaviele G. Qu C, et al. Among authors: mcgeough md. FASEB J. 2015 Apr;29(4):1269-79. doi: 10.1096/fj.14-264804. Epub 2014 Dec 4. FASEB J. 2015. PMID: 25477279 Free PMC article.
27 results