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Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity.
Smith S, Fox J, Mejia M, Ruangpradit W, Saberi A, Kim S, Choi Y, Oh S, Wang Y, Choi K, Li L, Hendrickson EA, Takeda S, Muller M, Myung K. Smith S, et al. Among authors: takeda s. PLoS One. 2014 Jan 23;9(1):e87203. doi: 10.1371/journal.pone.0087203. eCollection 2014. PLoS One. 2014. PMID: 24466340 Free PMC article.
A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia.
Shen X, Wang R, Kim MJ, Hu Q, Hsu CC, Yao J, Klages-Mundt N, Tian Y, Lynn E, Brewer TF, Zhang Y, Arun B, Gan B, Andreeff M, Takeda S, Chen J, Park JI, Shi X, Chang CJ, Jung SY, Qin J, Li L. Shen X, et al. Among authors: takeda s. Mol Cell. 2020 Dec 17;80(6):1013-1024.e6. doi: 10.1016/j.molcel.2020.11.040. Mol Cell. 2020. PMID: 33338401 Free PMC article.
Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells.
Nojima K, Hochegger H, Saberi A, Fukushima T, Kikuchi K, Yoshimura M, Orelli BJ, Bishop DK, Hirano S, Ohzeki M, Ishiai M, Yamamoto K, Takata M, Arakawa H, Buerstedde JM, Yamazoe M, Kawamoto T, Araki K, Takahashi JA, Hashimoto N, Takeda S, Sonoda E. Nojima K, et al. Among authors: takeda s. Cancer Res. 2005 Dec 15;65(24):11704-11. doi: 10.1158/0008-5472.CAN-05-1214. Cancer Res. 2005. PMID: 16357182
3,825 results