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Dose escalation prophylactic donor lymphocyte infusion after T-cell depleted matched related donor allogeneic hematopoietic cell transplantation is feasible and results in higher donor chimerism, faster immune re-constitution, and prolonged progression-free survival.
Kothari S, Artz AS, Lee SM, Fulton N, Park JH, Stock W, Larson RA, Odenike O, Kline J, LaBelle J, Kosuri S, Riedell P, Nakamura Y, Bishop MR, Liu H. Kothari S, et al. Among authors: nakamura y. Bone Marrow Transplant. 2020 Jun;55(6):1161-1168. doi: 10.1038/s41409-020-0798-4. Epub 2020 Jan 28. Bone Marrow Transplant. 2020. PMID: 31992847 Clinical Trial.
WT1 peptide vaccine in Montanide in contrast to poly ICLC, is able to induce WT1-specific immune response with TCR clonal enrichment in myeloid leukemia.
Liu H, Zha Y, Choudhury N, Malnassy G, Fulton N, Green M, Park JH, Nakamura Y, Larson RA, Salazar AM, Odenike O, Gajewski TF, Stock W. Liu H, et al. Among authors: nakamura y. Exp Hematol Oncol. 2018 Jan 11;7:1. doi: 10.1186/s40164-018-0093-x. eCollection 2018. Exp Hematol Oncol. 2018. PMID: 29344432 Free PMC article.
The era of immunogenomics/immunopharmacogenomics.
Zewde M, Kiyotani K, Park JH, Fang H, Yap KL, Yew PY, Alachkar H, Kato T, Mai TH, Ikeda Y, Matsuda T, Liu X, Ren L, Deng B, Harada M, Nakamura Y. Zewde M, et al. Among authors: nakamura y. J Hum Genet. 2018 Jul;63(8):865-875. doi: 10.1038/s10038-018-0468-1. Epub 2018 May 21. J Hum Genet. 2018. PMID: 29785006 Review.
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