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The Dual GLP-1/GIP Receptor Agonist DA4-JC Shows Superior Protective Properties Compared to the GLP-1 Analogue Liraglutide in the APP/PS1 Mouse Model of Alzheimer's Disease.
Maskery M, Goulding EM, Gengler S, Melchiorsen JU, Rosenkilde MM, Hölscher C. Maskery M, et al. Among authors: melchiorsen ju. Am J Alzheimers Dis Other Demen. 2020 Jan-Dec;35:1533317520953041. doi: 10.1177/1533317520953041. Am J Alzheimers Dis Other Demen. 2020. PMID: 32959677 Free PMC article.
Rare Heterozygous Loss-of-Function Variants in the Human GLP-1 Receptor Are Not Associated With Cardiometabolic Phenotypes.
Melchiorsen JU, Sørensen KV, Bork-Jensen J, Kizilkaya HS, Gasbjerg LS, Hauser AS, Rungby J, Sørensen HT, Vaag A, Nielsen JS, Pedersen O, Linneberg A, Hartmann B, Gjesing AP, Holst JJ, Hansen T, Rosenkilde MM, Grarup N. Melchiorsen JU, et al. J Clin Endocrinol Metab. 2023 Oct 18;108(11):2821-2833. doi: 10.1210/clinem/dgad290. J Clin Endocrinol Metab. 2023. PMID: 37235780 Free PMC article.
Altered desensitization and internalization patterns of rodent versus human glucose-dependent insulinotropic polypeptide (GIP) receptors. An important drug discovery challenge.
Gasbjerg LS, Rasmussen RS, Dragan A, Lindquist P, Melchiorsen JU, Stepniewski TM, Schiellerup S, Tordrup EK, Gadgaard S, Kizilkaya HS, Willems S, Zhong Y, Wang Y, Wright SC, Lauschke VM, Hartmann B, Holst JJ, Selent J, Rosenkilde MM. Gasbjerg LS, et al. Among authors: melchiorsen ju. Br J Pharmacol. 2024 Jul 1. doi: 10.1111/bph.16478. Online ahead of print. Br J Pharmacol. 2024. PMID: 38952084