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An improved organotypic cell culture system to study tissue-resident macrophages ex vivo.
Aktories P, Petry P, Glatz P, Andrieux G, Oschwald A, Botterer H, Gorka O, Erny D, Boerries M, Henneke P, Groß O, Prinz M, Kierdorf K. Aktories P, et al. Among authors: gross o. Cell Rep Methods. 2022 Jul 26;2(8):100260. doi: 10.1016/j.crmeth.2022.100260. eCollection 2022 Aug 22. Cell Rep Methods. 2022. PMID: 36046625 Free PMC article.
Metabolic rewiring tunes dermal macrophages in staphylococcal skin infection.
Forde AJ, Kolter J, Zwicky P, Baasch S, Lohrmann F, Eckert M, Gres V, Lagies S, Gorka O, Rambold AS, Buescher JM, Kammerer B, Lachmann N, Prinz M, Groß O, Pearce EJ, Becher B, Henneke P. Forde AJ, et al. Among authors: gross o. Sci Immunol. 2023 Aug 18;8(86):eadg3517. doi: 10.1126/sciimmunol.adg3517. Epub 2023 Aug 11. Sci Immunol. 2023. PMID: 37566679
Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation.
Saller BS, Wöhrle S, Fischer L, Dufossez C, Ingerl IL, Kessler S, Mateo-Tortola M, Gorka O, Lange F, Cheng Y, Neuwirt E, Marada A, Koentges C, Urban C, Aktories P, Reuther P, Giese S, Kirschnek S, Mayer C, Pilic J, Falquez-Medina H, Oelgeklaus A, Deepagan VG, Shojaee F, Zimmermann JA, Weber D, Tai YH, Crois A, Ciminski K, Peyronnet R, Brandenburg KS, Wu G, Baumeister R, Heimbucher T, Rizzi M, Riedel D, Helmstädter M, Buescher J, Neumann K, Misgeld T, Kerschensteiner M, Walentek P, Kreutz C, Maurer U, Rambold AS, Vince JE, Edlich F, Malli R, Häcker G, Kierdorf K, Meisinger C, Köttgen A, Jakobs S, Weber ANR, Schwemmle M, Groß CJ, Groß O. Saller BS, et al. Among authors: gross o. Immunity. 2025 Jan 14;58(1):90-107.e11. doi: 10.1016/j.immuni.2024.10.012. Epub 2024 Nov 20. Immunity. 2025. PMID: 39571574 Free article.
Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation.
Hamarsheh S, Osswald L, Saller BS, Unger S, De Feo D, Vinnakota JM, Konantz M, Uhl FM, Becker H, Lübbert M, Shoumariyeh K, Schürch C, Andrieux G, Venhoff N, Schmitt-Graeff A, Duquesne S, Pfeifer D, Cooper MA, Lengerke C, Boerries M, Duyster J, Niemeyer CM, Erlacher M, Blazar BR, Becher B, Groß O, Brummer T, Zeiser R. Hamarsheh S, et al. Among authors: gross o. Nat Commun. 2020 Apr 3;11(1):1659. doi: 10.1038/s41467-020-15497-1. Nat Commun. 2020. PMID: 32246016 Free PMC article.
Immune modulatory effects of oncogenic KRAS in cancer.
Hamarsheh S, Groß O, Brummer T, Zeiser R. Hamarsheh S, et al. Among authors: gross o. Nat Commun. 2020 Oct 28;11(1):5439. doi: 10.1038/s41467-020-19288-6. Nat Commun. 2020. PMID: 33116132 Free PMC article. Review.
Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile.
Merz J, Nettesheim A, von Garlen S, Albrecht P, Saller BS, Engelmann J, Hertle L, Schäfer I, Dimanski D, König S, Karnbrock L, Bulatova K, Peikert A, Hoppe N, Hilgendorf I, von Zur Mühlen C, Wolf D, Groß O, Bode C, Zirlik A, Stachon P. Merz J, et al. Among authors: gross o. Purinergic Signal. 2021 Sep;17(3):481-492. doi: 10.1007/s11302-021-09798-3. Epub 2021 Jul 20. Purinergic Signal. 2021. PMID: 34282551 Free PMC article.
Cardiomyocyte-specific miR-100 overexpression preserves heart function under pressure overload in mice and diminishes fatty acid uptake as well as ROS production by direct suppression of Nox4 and CD36.
Smolka C, Schlösser D, Koentges C, Tarkhnishvili A, Gorka O, Pfeifer D, Bemtgen X, Asmussen A, Groß O, Diehl P, Moser M, Bode C, Bugger H, Grundmann S, Pankratz F. Smolka C, et al. Among authors: gross o. FASEB J. 2021 Nov;35(11):e21956. doi: 10.1096/fj.202100829RR. FASEB J. 2021. PMID: 34605573
287 results