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Page 1
Hypoxia ameliorates brain hyperoxia and NAD+ deficiency in a murine model of Leigh syndrome.
Grange RMH, Sharma R, Shah H, Reinstadler B, Goldberger O, Cooper MK, Nakagawa A, Miyazaki Y, Hindle AG, Batten AJ, Wojtkiewicz GR, Schleifer G, Bagchi A, Marutani E, Malhotra R, Bloch DB, Ichinose F, Mootha VK, Zapol WM. Grange RMH, et al. Among authors: zapol wm. Mol Genet Metab. 2021 May;133(1):83-93. doi: 10.1016/j.ymgme.2021.03.005. Epub 2021 Mar 11. Mol Genet Metab. 2021. PMID: 33752971 Free PMC article.
Impaired hypoxic pulmonary vasoconstriction in a mouse model of Leigh syndrome.
Schleifer G, Marutani E, Ferrari M, Sharma R, Skinner O, Goldberger O, Grange RMH, Peneyra K, Malhotra R, Wepler M, Ichinose F, Bloch DB, Mootha VK, Zapol WM. Schleifer G, et al. Among authors: zapol wm. Am J Physiol Lung Cell Mol Physiol. 2019 Feb 1;316(2):L391-L399. doi: 10.1152/ajplung.00419.2018. Epub 2018 Dec 6. Am J Physiol Lung Cell Mol Physiol. 2019. PMID: 30520688 Free PMC article.
Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation.
Jain IH, Zazzeron L, Goldberger O, Marutani E, Wojtkiewicz GR, Ast T, Wang H, Schleifer G, Stepanova A, Brepoels K, Schoonjans L, Carmeliet P, Galkin A, Ichinose F, Zapol WM, Mootha VK. Jain IH, et al. Among authors: zapol wm. Cell Metab. 2019 Oct 1;30(4):824-832.e3. doi: 10.1016/j.cmet.2019.07.006. Epub 2019 Aug 8. Cell Metab. 2019. PMID: 31402314 Free PMC article.
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis.
Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK. Ast T, et al. Among authors: zapol wm. Cell. 2019 May 30;177(6):1507-1521.e16. doi: 10.1016/j.cell.2019.03.045. Epub 2019 Apr 25. Cell. 2019. PMID: 31031004 Free PMC article.
Inhaled NO as a therapeutic agent.
Bloch KD, Ichinose F, Roberts JD Jr, Zapol WM. Bloch KD, et al. Among authors: zapol wm. Cardiovasc Res. 2007 Jul 15;75(2):339-48. doi: 10.1016/j.cardiores.2007.04.014. Epub 2007 May 4. Cardiovasc Res. 2007. PMID: 17544387 Free PMC article. Review.
In 1991, Frostell and colleagues reported that breathing low concentrations of nitric oxide (NO) decreased pulmonary artery pressure (PAP) in awake lambs with experimental pulmonary hypertension (PH) [Frostell C, Fratacci MD, Wain JC, Jones R, Zapol WM. Inhaled nitr …
In 1991, Frostell and colleagues reported that breathing low concentrations of nitric oxide (NO) decreased pulmonary artery pressure (PAP) i …
Inhaled nitric oxide.
Yu B, Ichinose F, Bloch DB, Zapol WM. Yu B, et al. Among authors: zapol wm. Br J Pharmacol. 2019 Jan;176(2):246-255. doi: 10.1111/bph.14512. Epub 2018 Nov 16. Br J Pharmacol. 2019. PMID: 30288739 Free PMC article. Review.
317 results