O'Rourke A - Search Results

1

Mechanism-of-Action Classification of Antibiotics by Global Transcriptome Profiling.

O'Rourke A, Beyhan S, Choi Y, Morales P, Chan AP, Espinoza JL, Dupont CL, Meyer KJ, Spoering A, Lewis K, Nierman WC, Nelson KE. O'Rourke A, et al. Antimicrob Agents Chemother. 2020 Feb 21;64(3):e01207-19. doi: 10.1128/AAC.01207-19. Print 2020 Feb 21. Antimicrob Agents Chemother. 2020. PMID: 31907190 Free PMC article.

2

Predicting antimicrobial mechanism-of-action from transcriptomes: A generalizable explainable artificial intelligence approach.

Espinoza JL, Dupont CL, O'Rourke A, Beyhan S, Morales P, Spoering A, Meyer KJ, Chan AP, Choi Y, Nierman WC, Lewis K, Nelson KE. Espinoza JL, et al. PLoS Comput Biol. 2021 Mar 29;17(3):e1008857. doi: 10.1371/journal.pcbi.1008857. eCollection 2021 Mar. PLoS Comput Biol. 2021. PMID: 33780444 Free PMC article.

3

Predictive Signatures of 19 Antibiotic-Induced Escherichia coli Proteomes.

Yu Y, O'Rourke A, Lin YH, Singh H, Eguez RV, Beyhan S, Nelson KE. Yu Y, et al. ACS Infect Dis. 2020 Aug 14;6(8):2120-2129. doi: 10.1021/acsinfecdis.0c00196. Epub 2020 Aug 2. ACS Infect Dis. 2020. PMID: 32673475

4

A new antibiotic selectively kills Gram-negative pathogens.

Imai Y, Meyer KJ, Iinishi A, Favre-Godal Q, Green R, Manuse S, Caboni M, Mori M, Niles S, Ghiglieri M, Honrao C, Ma X, Guo JJ, Makriyannis A, Linares-Otoya L, Böhringer N, Wuisan ZG, Kaur H, Wu R, Mateus A, Typas A, Savitski MM, Espinoza JL, O'Rourke A, Nelson KE, Hiller S, Noinaj N, Schäberle TF, D'Onofrio A, Lewis K. Imai Y, et al. Nature. 2019 Dec;576(7787):459-464. doi: 10.1038/s41586-019-1791-1. Epub 2019 Nov 20. Nature. 2019. PMID: 31747680 Free PMC article.

5

Author Correction: A new antibiotic selectively kills Gram-negative pathogens.

Imai Y, Meyer KJ, Iinishi A, Favre-Godal Q, Green R, Manuse S, Caboni M, Mori M, Niles S, Ghiglieri M, Honrao C, Ma X, Guo JJ, Makriyannis A, Linares-Otoya L, Böhringer N, Wuisan ZG, Kaur H, Wu R, Mateus A, Typas A, Savitski MM, Espinoza JL, O'Rourke A, Nelson KE, Hiller S, Noinaj N, Schäberle TF, D'Onofrio A, Lewis K. Imai Y, et al. Nature. 2020 Apr;580(7802):E3. doi: 10.1038/s41586-020-2063-9. Nature. 2020. PMID: 32269338

6

Genomic and phenotypic characterization of Burkholderia isolates from the potable water system of the International Space Station.

O'Rourke A, Lee MD, Nierman WC, Everroad RC, Dupont CL. O'Rourke A, et al. PLoS One. 2020 Feb 19;15(2):e0227152. doi: 10.1371/journal.pone.0227152. eCollection 2020. PLoS One. 2020. PMID: 32074104 Free PMC article.

7

Reference-guided metagenomics reveals genome-level evidence of potential microbial transmission from the ISS environment to an astronaut's microbiome.

Lee MD, O'Rourke A, Lorenzi H, Bebout BM, Dupont CL, Everroad RC. Lee MD, et al. iScience. 2021 Jan 29;24(2):102114. doi: 10.1016/j.isci.2021.102114. eCollection 2021 Feb 19. iScience. 2021. PMID: 33659879 Free PMC article.

8

Following the Astrobiology Roadmap: Origins, Habitability and Future Exploration.

O'Rourke A, Zoumplis A, Wilburn P, Lee MD, Lee Z, Vecina M, Mercader K. O'Rourke A, et al. Curr Issues Mol Biol. 2020;38:1-32. doi: 10.21775/cimb.038.001. Epub 2020 Jan 22. Curr Issues Mol Biol. 2020. PMID: 31967574 Free article.

9

Alkaloids from the Sponge Stylissa carteri Present Prospective Scaffolds for the Inhibition of Human Immunodeficiency Virus 1 (HIV-1).

O'Rourke A, Kremb S, Bader TM, Helfer M, Schmitt-Kopplin P, Gerwick WH, Brack-Werner R, Voolstra CR. O'Rourke A, et al. Mar Drugs. 2016 Feb 4;14(2):28. doi: 10.3390/md14020028. Mar Drugs. 2016. PMID: 26861355 Free PMC article.

10

Identification of a 3-Alkylpyridinium Compound from the Red Sea Sponge Amphimedon chloros with In Vitro Inhibitory Activity against the West Nile Virus NS3 Protease.

O'Rourke A, Kremb S, Duggan BM, Sioud S, Kharbatia N, Raji M, Emwas AH, Gerwick WH, Voolstra CR. O'Rourke A, et al. Molecules. 2018 Jun 18;23(6):1472. doi: 10.3390/molecules23061472. Molecules. 2018. PMID: 29912151 Free PMC article.

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