Larsen SD - Search Results

1

Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors.

Rowlands RA, Cato MC, Waldschmidt HV, Bouley RA, Chen Q, Avramova L, Larsen SD, Tesmer JJG, White AD. Rowlands RA, et al. Among authors: larsen sd. ACS Med Chem Lett. 2019 Nov 12;10(12):1628-1634. doi: 10.1021/acsmedchemlett.9b00365. eCollection 2019 Dec 12. ACS Med Chem Lett. 2019. PMID: 31857838 Free PMC article.

2

Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog.

Homan KT, Wu E, Wilson MW, Singh P, Larsen SD, Tesmer JJ. Homan KT, et al. Among authors: larsen sd. Mol Pharmacol. 2014 Feb;85(2):237-48. doi: 10.1124/mol.113.089631. Epub 2013 Nov 12. Mol Pharmacol. 2014. PMID: 24220010 Free PMC article.

3

X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases.

Báez-Santos YM, Barraza SJ, Wilson MW, Agius MP, Mielech AM, Davis NM, Baker SC, Larsen SD, Mesecar AD. Báez-Santos YM, et al. Among authors: larsen sd. J Med Chem. 2014 Mar 27;57(6):2393-412. doi: 10.1021/jm401712t. Epub 2014 Mar 14. J Med Chem. 2014. PMID: 24568342 Free PMC article.

4

Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor.

Homan KT, Waldschmidt HV, Glukhova A, Cannavo A, Song J, Cheung JY, Koch WJ, Larsen SD, Tesmer JJG. Homan KT, et al. Among authors: larsen sd. J Biol Chem. 2015 Aug 21;290(34):20649-20659. doi: 10.1074/jbc.M115.647370. Epub 2015 Jun 1. J Biol Chem. 2015. PMID: 26032411 Free PMC article.

5

Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors.

Waldschmidt HV, Homan KT, Cruz-Rodríguez O, Cato MC, Waninger-Saroni J, Larimore KM, Cannavo A, Song J, Cheung JY, Kirchhoff PD, Koch WJ, Tesmer JJ, Larsen SD. Waldschmidt HV, et al. Among authors: larsen sd. J Med Chem. 2016 Apr 28;59(8):3793-807. doi: 10.1021/acs.jmedchem.5b02000. Epub 2016 Apr 13. J Med Chem. 2016. PMID: 27050625 Free PMC article.

6

Occludin S471 Phosphorylation Contributes to Epithelial Monolayer Maturation.

Bolinger MT, Ramshekar A, Waldschmidt HV, Larsen SD, Bewley MC, Flanagan JM, Antonetti DA. Bolinger MT, et al. Among authors: larsen sd. Mol Cell Biol. 2016 Jul 14;36(15):2051-66. doi: 10.1128/MCB.00053-16. Print 2016 Aug 1. Mol Cell Biol. 2016. PMID: 27185880 Free PMC article.

7

Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.

Waldschmidt HV, Homan KT, Cato MC, Cruz-Rodríguez O, Cannavo A, Wilson MW, Song J, Cheung JY, Koch WJ, Tesmer JJ, Larsen SD. Waldschmidt HV, et al. Among authors: larsen sd. J Med Chem. 2017 Apr 13;60(7):3052-3069. doi: 10.1021/acs.jmedchem.7b00112. Epub 2017 Mar 29. J Med Chem. 2017. PMID: 28323425 Free PMC article.

8

Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors.

Bouley R, Waldschmidt HV, Cato MC, Cannavo A, Song J, Cheung JY, Yao XQ, Koch WJ, Larsen SD, Tesmer JJG. Bouley R, et al. Among authors: larsen sd. Mol Pharmacol. 2017 Dec;92(6):707-717. doi: 10.1124/mol.117.110130. Epub 2017 Oct 25. Mol Pharmacol. 2017. PMID: 29070696 Free PMC article.

9

Utilizing a structure-based docking approach to develop potent G protein-coupled receptor kinase (GRK) 2 and 5 inhibitors.

Waldschmidt HV, Bouley R, Kirchhoff PD, Lee P, Tesmer JJG, Larsen SD. Waldschmidt HV, et al. Among authors: larsen sd. Bioorg Med Chem Lett. 2018 May 15;28(9):1507-1515. doi: 10.1016/j.bmcl.2018.03.082. Epub 2018 Mar 30. Bioorg Med Chem Lett. 2018. PMID: 29627263 Free PMC article.

10

Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy.

Huddle BC, Grimley E, Buchman CD, Chtcherbinine M, Debnath B, Mehta P, Yang K, Morgan CA, Li S, Felton J, Sun D, Mehta G, Neamati N, Buckanovich RJ, Hurley TD, Larsen SD. Huddle BC, et al. Among authors: larsen sd. J Med Chem. 2018 Oct 11;61(19):8754-8773. doi: 10.1021/acs.jmedchem.8b00930. Epub 2018 Sep 28. J Med Chem. 2018. PMID: 30221940 Free PMC article.

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