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A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1.
Le Nours J, Gherardin NA, Ramarathinam SH, Awad W, Wiede F, Gully BS, Khandokar Y, Praveena T, Wubben JM, Sandow JJ, Webb AI, von Borstel A, Rice MT, Redmond SJ, Seneviratna R, Sandoval-Romero ML, Li S, Souter MNT, Eckle SBG, Corbett AJ, Reid HH, Liu L, Fairlie DP, Giles EM, Westall GP, Tothill RW, Davey MS, Berry R, Tiganis T, McCluskey J, Pellicci DG, Purcell AW, Uldrich AP, Godfrey DI, Rossjohn J. Le Nours J, et al. Among authors: ramarathinam sh. Science. 2019 Dec 20;366(6472):1522-1527. doi: 10.1126/science.aav3900. Science. 2019. PMID: 31857486
Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes.
Petersen J, Wurzbacher SJ, Williamson NA, Ramarathinam SH, Reid HH, Nair AK, Zhao AY, Nastovska R, Rudge G, Rossjohn J, Purcell AW. Petersen J, et al. Among authors: ramarathinam sh. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2776-81. doi: 10.1073/pnas.0812901106. Epub 2009 Feb 5. Proc Natl Acad Sci U S A. 2009. PMID: 19196958 Free PMC article.
MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape.
Pymm P, Illing PT, Ramarathinam SH, O'Connor GM, Hughes VA, Hitchen C, Price DA, Ho BK, McVicar DW, Brooks AG, Purcell AW, Rossjohn J, Vivian JP. Pymm P, et al. Among authors: ramarathinam sh. Nat Struct Mol Biol. 2017 Apr;24(4):387-394. doi: 10.1038/nsmb.3381. Epub 2017 Feb 20. Nat Struct Mol Biol. 2017. PMID: 28218747 Free PMC article.
New insights and approaches for analyses of immunopeptidomes.
Illing PT, Ramarathinam SH, Purcell AW. Illing PT, et al. Among authors: ramarathinam sh. Curr Opin Immunol. 2022 Aug;77:102216. doi: 10.1016/j.coi.2022.102216. Epub 2022 Jun 15. Curr Opin Immunol. 2022. PMID: 35716458 Review.
46 results