Yang JJ - Search Results

1

Discovery and Characterization of 1H-1,2,3-Triazole Derivatives as Novel Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy.

Yang JJ, Yu WW, Hu LL, Liu WJ, Lin XH, Wang W, Zhang Q, Wang PL, Tang SW, Wang X, Liu M, Lu W, Zhang HK. Yang JJ, et al. J Med Chem. 2020 Jan 23;63(2):569-590. doi: 10.1021/acs.jmedchem.9b01269. Epub 2020 Jan 2. J Med Chem. 2020. PMID: 31855426

2

Synthesis of urea analogues bearing N-alkyl-N'-(thiophen-2-yl) scaffold and evaluation of their innate immune response to toll-like receptors.

Chen Z, Cen X, Yang J, Lin Z, Liu M, Cheng K. Chen Z, et al. Eur J Med Chem. 2019 May 1;169:42-52. doi: 10.1016/j.ejmech.2019.02.067. Epub 2019 Mar 1. Eur J Med Chem. 2019. PMID: 30852386

3

Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer.

Lu W, Yu W, He J, Liu W, Yang J, Lin X, Zhang Y, Wang X, Jiang W, Luo J, Zhang Q, Yang H, Peng S, Yi Z, Ren S, Chen J, Siwko S, Nussinov R, Cheng F, Zhang H, Liu M. Lu W, et al. EMBO Mol Med. 2021 Jan 11;13(1):e12798. doi: 10.15252/emmm.202012798. Epub 2020 Dec 7. EMBO Mol Med. 2021. PMID: 33283987 Free PMC article.

4

From a Designer Drug to the Discovery of Selective Cannabinoid Type 2 Receptor Agonists with Favorable Pharmacokinetic Profiles for the Treatment of Systemic Sclerosis.

Jiang BE, Jiang X, Zhang Q, Liang Q, Qiu ZL, Sun XB, Yang JJ, Chen S, Yi C, Chai X, Liu M, Yu LF, Lu W, Zhang HK. Jiang BE, et al. Among authors: yang jj. J Med Chem. 2021 Jan 14;64(1):385-403. doi: 10.1021/acs.jmedchem.0c01023. Epub 2020 Dec 31. J Med Chem. 2021. PMID: 33382613

5

Design, Synthesis, and Structure-Activity Relationship of N-Aryl-N'-(thiophen-2-yl)thiourea Derivatives as Novel and Specific Human TLR1/2 Agonists for Potential Cancer Immunotherapy.

Chen Z, Zhang L, Yang J, Zheng L, Hu F, Duan S, Nandakumar KS, Liu S, Yin H, Cheng K. Chen Z, et al. J Med Chem. 2021 Jun 10;64(11):7371-7389. doi: 10.1021/acs.jmedchem.0c02266. Epub 2021 May 24. J Med Chem. 2021. PMID: 34029463

6

Discovery of isoliquiritigenin analogues that reverse acute hepatitis by inhibiting macrophage polarization.

Yang J, Hu F, Guo C, Liang Y, Song H, Cheng K. Yang J, et al. Bioorg Chem. 2021 Sep;114:105043. doi: 10.1016/j.bioorg.2021.105043. Epub 2021 Jun 1. Bioorg Chem. 2021. PMID: 34120019

7

Single-Cell Analysis Reveals EP4 as a Target for Restoring T-Cell Infiltration and Sensitizing Prostate Cancer to Immunotherapy.

Peng S, Hu P, Xiao YT, Lu W, Guo D, Hu S, Xie J, Wang M, Yu W, Yang J, Chen H, Zhang X, Zhu Y, Wang Y, Yang Y, Zhu G, Chen S, Wang J, Zhang B, Chen W, Wu H, Sun Z, Ding T, Zhang H, Yi Z, Liu M, Ren S. Peng S, et al. Clin Cancer Res. 2022 Feb 1;28(3):552-567. doi: 10.1158/1078-0432.CCR-21-0299. Epub 2021 Nov 5. Clin Cancer Res. 2022. PMID: 34740924

8

A Novel Small Molecular Prostaglandin Receptor EP4 Antagonist, L001, Suppresses Pancreatic Cancer Metastasis.

He J, Lin X, Meng F, Zhao Y, Wang W, Zhang Y, Chai X, Zhang Y, Yu W, Yang J, Li G, Du X, Zhang H, Liu M, Lu W. He J, et al. Molecules. 2022 Feb 11;27(4):1209. doi: 10.3390/molecules27041209. Molecules. 2022. PMID: 35208999 Free PMC article.

9

PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis.

Jiang W, Jin Y, Zhang S, Ding Y, Huo K, Yang J, Zhao L, Nian B, Zhong TP, Lu W, Zhang H, Cao X, Shah KM, Wang N, Liu M, Luo J. Jiang W, et al. Bone Res. 2022 Mar 9;10(1):27. doi: 10.1038/s41413-022-00201-4. Bone Res. 2022. PMID: 35260562 Free PMC article.

10

Scaffold Hopping Strategy to Identify Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy.

Wang W, He J, Yang J, Zhang C, Cheng Z, Zhang Y, Zhang Q, Wang P, Tang S, Wang X, Liu M, Lu W, Zhang HK. Wang W, et al. J Med Chem. 2022 Jun 9;65(11):7896-7917. doi: 10.1021/acs.jmedchem.2c00448. Epub 2022 May 31. J Med Chem. 2022. PMID: 35640059

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